基质金属蛋白酶作为阻塞性睡眠呼吸暂停严重程度的可能生物标志物——系统评价。
Matrix metalloproteinases as possible biomarkers of obstructive sleep apnea severity - A systematic review.
机构信息
Division of Respiratory, Critical Care and Sleep Medicine, University of Saskatchewan, Saskatoon, Canada; Department of Medical Laboratory Diagnostics, Division of Clinical Chemistry, Wroclaw Medical University, Wroclaw, Poland.
Department of Medical Laboratory Diagnostics, Division of Clinical Chemistry, Wroclaw Medical University, Wroclaw, Poland.
出版信息
Sleep Med Rev. 2019 Aug;46:9-16. doi: 10.1016/j.smrv.2019.03.010. Epub 2019 Mar 30.
Obstructive sleep apnea is an underdiagnosed sleep-related breathing disorder affecting millions of people. Recurrent episodes of apnea/hypopnea result in intermittent hypoxia leading to oxidative stress. Obstructive sleep apnea is considered an independent risk factor for cardiovascular disease but the exact pathophysiology of adverse cardiovascular outcomes of obstructive sleep apnea has not been fully elucidated. Matrix metalloproteinases (MMPs) have been associated with both oxidative stress and cardiovascular diseases. Hypoxic conditions were shown to influence MMP expression, secretion and activity. Moreover, matrix metalloproteinases contribute to ischemia/reperfusion injury. Therefore, action of matrix metalloproteinases can provide a possible molecular mechanism linking obstructive sleep apnea with oxidative stress and cardiovascular disease. The aim of this paper was to review the current evidence of association between matrix metalloproteinases and obstructive sleep apnea with focus on hypoxemia and severity of obstructive sleep apnea.
阻塞性睡眠呼吸暂停是一种未被充分诊断的与睡眠相关的呼吸障碍，影响着数百万人。呼吸暂停/低通气反复发作会导致间歇性缺氧，进而导致氧化应激。阻塞性睡眠呼吸暂停被认为是心血管疾病的独立危险因素，但阻塞性睡眠呼吸暂停对心血管不良后果的确切病理生理学尚未完全阐明。基质金属蛋白酶 (MMPs) 与氧化应激和心血管疾病都有关。缺氧条件会影响 MMP 的表达、分泌和活性。此外，基质金属蛋白酶会导致缺血/再灌注损伤。因此，基质金属蛋白酶的作用可以为阻塞性睡眠呼吸暂停与氧化应激和心血管疾病之间的联系提供一个可能的分子机制。本文旨在回顾基质金属蛋白酶与阻塞性睡眠呼吸暂停之间的关联的现有证据，重点关注低氧血症和阻塞性睡眠呼吸暂停的严重程度。
Zotero 插件