Department of Family Medicine, Busan Paik Hospital, College of Medicine, Inje University, Busan, Republic of Korea.
J Clin Densitom. 2020 Apr-Jun;23(2):278-285. doi: 10.1016/j.jocd.2019.04.003. Epub 2019 Apr 11.
INTRODUCTION/BACKGROUND: This study aimed to evaluate the effect of handgrip strength on the associations of body mass index and metabolic syndrome with an indicator of nonalcoholic fatty liver disease in adolescents.
In data of 1690 adolescents aged 10-18 yr from the Korea National Health and Nutrition Examination Survey 2014-2016, alanine amino-transferase levels, age, sex, bodyweight-, sex-, and age-standardized handgrip strength, age- and sex-specific body mass index Z-scores, and metabolic syndrome severity scores were assessed. Nonalcoholic fatty liver disease was defined based on alanine amino-transferase levels (boys ≥52U/L, girls ≥44U/L) in adolescents who were overweight. Moderation analysis via the PROCESS procedure was performed.
The prevalence of nonalcoholic fatty liver disease was 1.5% among all adolescents and 6.7% among those who were overweight. In all adolescents and adolescents who were overweight, age- and sex-specific body mass index Z-scores and metabolic syndrome scores had positive associations with nonalcoholic fatty liver disease after adjusting for bodyweight-, sex-, and age-standardized handgrip strength. Bodyweight-, sex-, and age-standardized handgrip strength had an inverse association with nonalcoholic fatty liver disease after adjusting for metabolic syndrome scores, and this association became nonsignificant after adjusting for age- and sex-specific body mass index Z-scores. There were positive associations between age- and sex-specific body mass index Z-scores and alanine amino-transferase levels when bodyweight-, sex-, and age-standardized handgrip strength values were ≤-0.13 in overweight adolescents and ≤0.74 in all adolescents, whereas these associations were nonsignificant or negative above those cut-off values. These cut-off values of bodyweight-, sex-, and age-standardized handgrip strength for the relationship between metabolic syndrome scores and alanine amino-transferase levels were -0.15 in overweight adolescents and 0.55 in all adolescents.
A higher bodyweight-, sex-, and age-standardized handgrip strength may attenuate the risk of obesity and metabolic syndrome for an indicator of nonalcoholic fatty liver disease in adolescents.
简介/背景：本研究旨在评估握力对青少年体重指数和代谢综合征与非酒精性脂肪肝指标之间关联的影响。
在 2014-2016 年韩国国家健康和营养检查调查的数据中，评估了 1690 名 10-18 岁青少年的丙氨酸氨基转移酶水平、年龄、性别、体重、性别和年龄标准化握力、年龄和性别特异性体重指数 Z 分数和代谢综合征严重程度评分。非酒精性脂肪肝是根据超重青少年丙氨酸氨基转移酶水平（男孩≥52U/L，女孩≥44U/L）定义的。通过 PROCESS 程序进行了调节分析。
所有青少年中非酒精性脂肪肝的患病率为 1.5%，超重青少年中为 6.7%。在所有青少年和超重青少年中，在调整体重、性别和年龄标准化握力后，年龄和性别特异性体重指数 Z 分数和代谢综合征评分与非酒精性脂肪肝呈正相关。在调整代谢综合征评分后，体重、性别和年龄标准化握力与非酒精性脂肪肝呈负相关，而在调整年龄和性别特异性体重指数 Z 分数后，这种相关性变得不显著。在超重青少年中，当体重、性别和年龄标准化握力值≤-0.13 或所有青少年中≤0.74 时，年龄和性别特异性体重指数 Z 分数与丙氨酸氨基转移酶水平之间存在正相关，而当这些值高于这些临界值时，这些相关性则不显著或为负相关。在超重青少年中，代谢综合征评分与丙氨酸氨基转移酶水平之间关系的体重、性别和年龄标准化握力的这些临界值为-0.15，而在所有青少年中为 0.55。
较高的体重、性别和年龄标准化握力可能会降低青少年肥胖和代谢综合征与非酒精性脂肪肝指标相关的风险。
