放射性肠炎治疗中的病理生理学与药理学视角

[Physiopathology and pharmacological perspectives in the treatment of radiation enteritis].

作者信息

Rehailia-Blanchard A, He M Y, Rancoule C, Vallard A, Espenel S, Nivet A, Magné N, Chargari C

机构信息

Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108, bis, rue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France.

Département de radiothérapie, CHU de Limoges, 2, avenue Martin-Luther-King, 87000 Limoges, France.

出版信息

Cancer Radiother. 2019 Jun;23(3):240-247. doi: 10.1016/j.canrad.2018.05.010. Epub 2019 May 3.

DOI:10.1016/j.canrad.2018.05.010

PMID:31060972

Abstract

The small intestine is an organ frequently exposed in abdominal and pelvic irradiations. Acute and late toxicity can sometimes be difficult to manage and can significantly affect the quality of life of patients. Currently there is no guideline on the management of acute and late side effects induced by therapeutic irradiation. The aim of this review is to summarize available data on the pathophysiology of radiation enteritis, and to highlight potential preventive strategies and principles of treatment of radiation enteritis.

摘要

小肠是腹部和盆腔放疗中经常受到照射的器官。急性和晚期毒性有时难以处理，会显著影响患者的生活质量。目前尚无关于治疗性放疗所致急、晚期副作用管理的指南。本综述的目的是总结放射性肠炎病理生理学的现有数据，并强调放射性肠炎潜在的预防策略和治疗原则。