Ladefoged K, Andersen P, Jørgensen J
Acta Med Scand. 1979;205(1-2):103-9. doi: 10.1111/j.0954-6820.1979.tb06011.x.
In a prospective consecutive study, 68 patients with various liver diseases and 67 control persons were examined for the occurrence of smooth muscle antibodies (SMA), antinuclear antibodies (ANA) and mitochondrial antibodies (MTA) of IgG, IgA and IgM class. A determination of serum immunoglobulins (S-IgG, S-IgA and S-IgM) was also performed. IgG-SMA in titres of greater than 80 occurred in 8 of 12 patients (67%) with hepatitis B antigen (HBag)-negative chronic active liver disease (CALD) and not in other diseases. Apart from one patient with primary biliary cirrhosis (PBC), IgG-ANA in titres of greater than 40 were likewise detected only in HBag-negative CALD (33%). The titres of IgG-SMA and IgG-ANA varied analogously with the biochemical liver parametres. There was a mutual exclusion between HBag and IgG-SMA/-ANA in titres of greater than 20, while IgM-SMA occured in titres of 80 in two patients with HBag-positive CALD. The incidence and titres of IgM-SMA and -ANA were not higher than in the controls. IgA-SMA and -ANA were detected only sporadically. The MTA demonstrated were of IgG PCLASS AND TITRES OF GREATER THAN 40 WERE FOUND ONLY IN PATIENTS WITH PBC (4 of 5). Som of the patients in all groups had an increased conenctration of one or more of the serum immunoglobulins. S-IgG levels were found to be significantly higher in CALD than in the other groups
在一项前瞻性连续性研究中，对68例患有各种肝脏疾病的患者和67名对照者进行了检查，以检测IgG、IgA和IgM类的平滑肌抗体（SMA）、抗核抗体（ANA）和线粒体抗体（MTA）。还进行了血清免疫球蛋白（S-IgG、S-IgA和S-IgM）的测定。在12例乙肝抗原（HBag）阴性的慢性活动性肝病（CALD）患者中，有8例（67%）的IgG-SMA滴度大于80，而其他疾病患者中未出现这种情况。除1例原发性胆汁性肝硬化（PBC）患者外，仅在HBag阴性的CALD患者中检测到滴度大于40的IgG-ANA（33%）。IgG-SMA和IgG-ANA的滴度与肝脏生化参数类似地变化。HBag与滴度大于20的IgG-SMA/-ANA之间相互排斥，而在2例HBag阳性的CALD患者中，IgM-SMA滴度为80。IgM-SMA和-ANA的发生率和滴度并不高于对照组。仅偶尔检测到IgA-SMA和-ANA。所检测到的MTA为IgG类，仅在PBC患者中发现滴度大于40（5例中有4例）。所有组中的一些患者一种或多种血清免疫球蛋白的浓度升高。发现CALD患者的S-IgG水平显著高于其他组。
