Husby G, Skrede S, Blomhoff J P, Jacobsen C D, Berg K, Gjone E
Scand J Gastroenterol. 1977;12(3):297-304. doi: 10.3109/00365527709180931.
Serum immunoglobulins and C3 levels, auto-antibodies to smooth muscle (SMA), mitochondria (MA), and nuclei (ANA), rheumatoid factors (RF), HB-antigen and HB-antibody were studied in 9 groups of liver disease. Hypergammaglobulinaemia was a prominent feature in most groups, IgG being particularly raised in active chronic hepatitis, IgM in primary biliary cirrhosis, and IgA in alcoholic liver disease, respectively. IgE was often increased in alcoholic liver disease and was frequently low in hepatic tumours, whereas IgD showed no typical pattern in any liver disorder. SMA was most frequently found in active chronic hepatitis (68%), and MA in primary biliary cirrhosis (58%), while ANA was detected in 50% of the patients with active chronic hepatitis. However, a pronounced over-lap of tissue antibodies was observed among the various groups of liver disease, particularly in active chronic hepatitis and primary biliary cirrhosis. The concurrent presence of SMA and ANA was most frequent in active chronic hepatitis. It was not excluded that antibody titres might have provided better diagnostic discrimination, since titration of antibodies was not performed. Low C3 levels in active chronic hepatitis were correlated with low levels of other liver-synthetized proteins, and no evidence was found of increased consumption by immunologic reactions.
对9组肝病患者的血清免疫球蛋白、C3水平、平滑肌自身抗体（SMA）、线粒体自身抗体（MA）、核自身抗体（ANA）、类风湿因子（RF）、乙肝抗原和乙肝抗体进行了研究。高球蛋白血症是大多数组的一个突出特征，在活动性慢性肝炎中IgG尤其升高，在原发性胆汁性肝硬化中IgM升高，在酒精性肝病中IgA升高。IgE在酒精性肝病中常升高，在肝肿瘤中常降低，而IgD在任何肝病中均无典型模式。SMA最常见于活动性慢性肝炎（68%），MA最常见于原发性胆汁性肝硬化（58%），而50%的活动性慢性肝炎患者可检测到ANA。然而，在不同组的肝病中观察到组织抗体有明显重叠，特别是在活动性慢性肝炎和原发性胆汁性肝硬化中。SMA和ANA同时存在在活动性慢性肝炎中最为常见。由于未进行抗体滴定，因此不能排除抗体滴度可能提供更好的诊断鉴别依据。活动性慢性肝炎中低C3水平与其他肝脏合成蛋白水平降低相关，未发现有免疫反应导致消耗增加的证据。
