Tavares Wilson R, Seca Ana M L
Faculty of Sciences and Technology, University of Azores, 9501-801 Ponta Delgada, Portugal.
cE3c-Centre for Ecology, Evolution and Environmental Changes/ Azorean Biodiversity Group & University of Azores, Rua Mãe de Deus, 9501-801 Ponta Delgada, Portugal.
Antioxidants (Basel). 2019 May 6;8(5):122. doi: 10.3390/antiox8050122.
An imbalance in the production of reactive oxygen species in the body can cause an increase of oxidative stress that leads to oxidative damage to cells and tissues, which culminates in the development or aggravation of some chronic diseases, such as inflammation, diabetes mellitus, cancer, cardiovascular disease, and obesity. Secondary metabolites from species can play an important role in the prevention and treatment of the oxidative stress-related diseases mentioned above. The databases Scopus, PubMed, and Web of Science and the combining terms , antioxidant and secondary metabolites were used in the research for this review. More than 120 articles are reviewed, highlighting the most active compounds with special emphasis on the elucidation of their antioxidative-stress mechanism of action, which increases the knowledge about their potential in the fight against inflammation, cancer, neurodegeneration, and diabetes. Alantolactone is the most polyvalent compound, reporting interesting EC values for several bioactivities, while 1--acetylbritannilactone can be pointed out as a promising lead compound for the development of analogues with interesting properties. The genus is a good bet as source of structurally diverse compounds with antioxidant activity that can act via different mechanisms to fight several oxidative stress-related human diseases, being useful for development of new drugs.
体内活性氧生成失衡会导致氧化应激增加，进而对细胞和组织造成氧化损伤，最终导致一些慢性疾病的发生或加重，如炎症、糖尿病、癌症、心血管疾病和肥胖症。植物的次生代谢产物在预防和治疗上述与氧化应激相关的疾病中可发挥重要作用。本综述研究使用了Scopus、PubMed和Web of Science数据库以及“抗氧化剂”和“次生代谢产物”等组合术语。共综述了120多篇文章，重点介绍了最具活性的化合物，并特别强调了对其抗氧化应激作用机制的阐释，这增加了人们对它们在对抗炎症、癌症、神经退行性变和糖尿病方面潜力的认识。土木香内酯是最具多效性的化合物，对多种生物活性均有有趣的半数效应浓度（EC）值，而1-乙酰大花旋覆花内酯可被视为开发具有有趣特性类似物的有前景的先导化合物。该属植物很有潜力作为具有抗氧化活性的结构多样化合物的来源，这些化合物可通过不同机制对抗多种与氧化应激相关的人类疾病，有助于开发新药。
