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J Infect. 2018 Nov;77(5):410-416. doi: 10.1016/j.jinf.2018.05.003. Epub 2018 May 17.
2
Association of body mass index with incident tuberculosis in Korea.体重指数与韩国结核病发病的相关性研究。
PLoS One. 2018 Apr 18;13(4):e0195104. doi: 10.1371/journal.pone.0195104. eCollection 2018.
3
Low body mass index and latent tuberculous infection: a systematic review and meta-analysis.低体重指数与潜伏性结核感染：系统评价和荟萃分析。
Int J Tuberc Lung Dis. 2018 Apr 1;22(4):358-365. doi: 10.5588/ijtld.17.0558.
4
Characteristics Associated with Negative Interferon-γ Release Assay Results in Culture-Confirmed Tuberculosis Patients, Texas, USA, 2013-2015.2013-2015 年美国德克萨斯州经培养确诊结核病患者中与干扰素-γ 释放试验阴性结果相关的特征。
Emerg Infect Dis. 2018 Mar;24(3):534-540. doi: 10.3201/eid2403.171633.
5
Influence of Age and Other Factors on Cytokine Expression Profiles in Healthy Children-A Systematic Review.年龄及其他因素对健康儿童细胞因子表达谱的影响——一项系统综述
Front Pediatr. 2017 Dec 14;5:255. doi: 10.3389/fped.2017.00255. eCollection 2017.
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Cytokine profiling in healthy children shows association of age with cytokine concentrations.健康儿童的细胞因子谱分析显示细胞因子浓度与年龄有关。
Sci Rep. 2017 Dec 19;7(1):17842. doi: 10.1038/s41598-017-17865-2.
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Drug-Resistant Tuberculosis among Children, China, 2006-2015.2006 - 2015年中国儿童耐多药结核病情况
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The sensitivity of the QuantiFERON-TB Gold Plus assay in Zambian adults with active tuberculosis.在赞比亚患有活动性结核病的成年人中，全血γ-干扰素释放试验增强版检测的敏感性。
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Association between parasitic infections and tuberculin skin test results in refugees.难民中寄生虫感染与结核菌素皮肤试验结果的关系。
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美国波士顿有寄生虫感染的移民人群中使用 QuantiFERON-TB Gold In-Tube 的可靠性。

QuantiFERON-TB Gold In-Tube reliability for immigrants with parasitic infections in Boston, USA.

机构信息

Department of Pediatrics, Section of Pediatric Infectious Diseases, Boston Medical Center, Department of Medicine, Section of Infectious Diseases, Boston Medical Center, Boston, Massachusetts.

Centre for Emerging Pathogens, Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey.

出版信息

Int J Tuberc Lung Dis. 2019 Apr 1;23(4):482-490. doi: 10.5588/ijtld.18.0540.

DOI:10.5588/ijtld.18.0540
PMID:31064628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6690781/
Abstract

SETTING Accurate testing and treatment for latent tuberculous infection is necessary for tuberculosis elimination. Certain parasite infections are associated with increased tuberculin skin test positivity; species-specific effects on QuantiFERON-TB Gold In-Tube (QGIT) have not been described. OBJECTIVE To determine whether infection with helminths or protozoa affects QGIT results. DESIGN We retrospectively analyzed QGIT and parasite testing results for immigrants screened in Boston, MA, USA, from 2012 to 2017. We also prospectively measured cytokines in QGIT supernatants for a subset ( = 68) with 1) helminths, 2) , 3) other protozoa, and 4) no parasites. RESULTS Of 527 immigrants screened, 141 (26.8%) were QGIT-positive and 229 (43.4%) had parasites detected: 27/527 (5.1%) had helminths and 202/527 (38.3%) protozoa. Cytokine analysis revealed increased interleukin-10 concentrations with protozoa ( = 0.04), and non-significantly higher T-helper 2 concentrations with helminths compared with no parasites. No significant differences emerged in QGIT positivity or interferon-gamma concentrations in any group. CONCLUSION Study results support the use of QGIT in parasite-endemic settings. .

摘要

背景 为了消除结核病，对潜伏性结核感染进行准确的检测和治疗是必要的。某些寄生虫感染与结核菌素皮肤试验阳性率增加有关；尚未描述针对 QuantiFERON-TB Gold In-Tube（QGIT）的物种特异性影响。 目的 确定寄生虫或原生动物感染是否影响 QGIT 结果。 设计 我们回顾性分析了 2012 年至 2017 年在美国马萨诸塞州波士顿筛查的移民的 QGIT 和寄生虫检测结果。我们还前瞻性地测量了一组（= 68）的 QGIT 上清液中的细胞因子，这些人具有 1）寄生虫，2），3）其他原生动物，和 4）无寄生虫。 结果 在 527 名接受筛查的移民中，141 名（26.8%）的 QGIT 呈阳性，229 名（43.4%）检测到寄生虫：27/527（5.1%）有寄生虫，202/527（38.3%）有原生动物。细胞因子分析显示，与无寄生虫相比，寄生虫组白细胞介素-10 浓度增加（= 0.04），辅助性 T 细胞 2 浓度升高，但无统计学意义。在任何一组中，QGIT 阳性率或干扰素-γ浓度均无显著差异。 结论 研究结果支持在寄生虫流行地区使用 QGIT。.