Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico.
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Obes Res Clin Pract. 2019 Jul-Aug;13(4):340-344. doi: 10.1016/j.orcp.2019.04.003. Epub 2019 May 4.
Curcuminoids are known anti-inflammatory molecules with multiple mechanisms of action while adiponectin is an anti-inflammatory molecule secreted by the adipocytes. Curcuminoids may upregulate the expression of adiponectin and thus modulate their levels in serum. A meta-analysis was performed to identify randomized controlled trials evaluating the effect of curcuminoids on adiponectin concentrations.
The search included PubMed-Medline, Scopus, ISI Web of Science and Google Scholar databases (from inception to October 20, 2018) and the quality of studies was assessed according to Cochrane criteria. Quantitative data synthesis was conducted using a random-effects model and sensitivity analysis by the leave-one out method. Additional analysis was performed to assess the impact of potential confounders on adiponectin levels.
The meta-analysis of five randomized clinical trials (n = 686) showed a significant elevation of plasma adiponectin concentrations following supplementation with curcuminoids (WMD: 6.47 ng/mL, 95% CI: 1.85, 11.10, p = 0.010; I = 94.85%). The effect size was robust in the leave-one-out sensitivity analysis and the effect size was not driven by a single study in the meta-analysis.
This meta-analysis showed a significant increase in plasma levels of adiponectin following curcuminoids therapy, which may be one of the mechanisms of anti-inflammatory activity of curcumin.
姜黄素是一种具有多种作用机制的抗炎分子，而脂联素是脂肪细胞分泌的抗炎分子。姜黄素可能上调脂联素的表达，从而调节其在血清中的水平。进行了一项荟萃分析，以确定评估姜黄素类对脂联素浓度影响的随机对照试验。
搜索包括 PubMed-Medline、Scopus、ISI Web of Science 和 Google Scholar 数据库（从开始到 2018 年 10 月 20 日），并根据 Cochrane 标准评估研究质量。使用随机效应模型进行定量数据综合，并通过逐一剔除法进行敏感性分析。还进行了额外的分析，以评估潜在混杂因素对脂联素水平的影响。
对五项随机临床试验（n=686）的荟萃分析表明，补充姜黄素后血浆脂联素浓度显著升高（WMD：6.47ng/ml，95%CI：1.85，11.10，p=0.010；I=94.85%）。逐一剔除法的敏感性分析表明，该效应大小稳健，荟萃分析中没有单个研究驱动该效应大小。
这项荟萃分析表明，姜黄素治疗后血浆脂联素水平显著升高，这可能是姜黄素抗炎活性的机制之一。
