Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai, Maharashtra, India.
Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai, Maharashtra, India. Correspondence to: Dr Prachi Karnik, Assistant Professor, Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra 400 022, India.
Indian Pediatr. 2019 Apr 15;56(4):287-293.
To compare efficacy of indigenous Ready-to-use Therapeutic Food (Medical Nutrition Therapy) with Standard Nutrition Therapy in children with Severe acute malnutrition.
Two facility-based and two community-based models: (i) Open prospective randomized controlled trial comparing Indigenous Ready-to-use Therapeutic Food (Medical Nutrition Therapy) with Standard Nutrition Therapy; (ii) Only Indigenous Ready-to-use Therapeutic Food (Medical Nutrition Therapy); (iii) Doorstep Child Care Centre; and (iv) Community-based Management of Acute Malnutrition.
(i) Urban Health Center, Dharavi, Mumbai; (ii) Two day care centers of Non-governmental Organization SNEHA - Mumbai; (iii) Urban slums, M East and L Ward, Mumbai.
1105 children aged 6-60 months in community or hospital inpatient/ outpatient department diagnosed as Severe Acute Malnutrition by WHO definition.
All subjects received either Indigenous Ready-to-use Therapeutic Food (Medical Nutrition Therapy) or Standard Nutrition Therapy (protein calorie rich diet) for eight weeks and followed up for next four months.
Mean rate of weight gain (g/kg/day), target weight, change in nutritional status.
Rate of weight gain was higher (P<0.05) at 2 weeks on indigenous Ready-to-use Therapeutic Food (Medical Nutrition Therapy) (5.63 g/kg/day) as compared to Standard Nutrition Therapy (3.43 g/kg/day). 61.2% subjects achieved target weight compared to 47.7% controls. At 8 weeks, 82.8% subjects recovered from Severe Acute Malnutrition compared to 19.3% controls (P<0.005). The results obtained in community were comparable to facility-based indigenous Ready-to-use Therapeutic Food (Medical Nutrition Therapy). The morbidity was less in study group at follow-up.
Indigenous Ready-to-use Therapeutic Food (Medical Nutrition Therapy) appeared to be superior to Standard Nutrition Therapy in promoting weight gain in children with Severe Acute Malnutrition.
比较本土即食治疗食品（医学营养疗法）与标准营养疗法在严重急性营养不良儿童中的疗效。
两种基于机构和两种基于社区的模式：（i）开放前瞻性随机对照试验，比较本土即食治疗食品（医学营养疗法）与标准营养疗法；（ii）仅使用本土即食治疗食品（医学营养疗法）；（iii）上门儿童护理中心；和（iv）社区管理急性营养不良。
（i）孟买达拉维市的城市健康中心；（ii）非政府组织 SNEHA 的两个日托中心-孟买；（iii）孟买的城市贫民窟，M 东区和 L 区。
1105 名年龄在 6-60 个月的社区或医院住院/门诊部门的儿童，根据世卫组织定义诊断为严重急性营养不良。
所有受试者均接受本土即食治疗食品（医学营养疗法）或标准营养疗法（富含蛋白质和卡路里的饮食）治疗八周，并在接下来的四个月内进行随访。
体重增加率（g/kg/天）、目标体重、营养状况变化。
在使用本土即食治疗食品（医学营养疗法）的第 2 周，体重增加率较高（P<0.05）（5.63 g/kg/天），而标准营养疗法（3.43 g/kg/天）。与对照组相比，61.2%的受试者达到了目标体重，而对照组为 47.7%。第 8 周时，82.8%的受试者从严重急性营养不良中恢复，而对照组为 19.3%（P<0.005）。在社区中获得的结果与基于机构的本土即食治疗食品（医学营养疗法）相当。在随访期间，研究组的发病率较低。
在促进严重急性营养不良儿童体重增加方面，本土即食治疗食品（医学营养疗法）似乎优于标准营养疗法。
