Department of Pediatrics, Gandhi Memorial Hospital and SS Medical College, Rewa, MP, India.
Indian Pediatr. 2013 Mar;50(3):295-9. doi: 10.1007/s13312-013-0097-x. Epub 2012 Oct 5.
To compare the efficacy of locally-prepared ready-to-use therapeutic food (LRUTF) and locally-prepared F100 diet in promoting weight-gain in children with severe acute malnutrition during rehabilitation phase in hospital.
Non-randomized Controlled trial.
Pediatric ward of tertiary care public hospital in Central India.
1 October, 2009 to 30th May, 2010.
Children aged 6 to 60 months, diagnosed as severe acute malnutrition and hospitalized during study period.
Random group allocation followed for selection of intervention and control cohorts. The control cohort enrolled during October 1, 2009 to January 31, 2010 received F100 while the intervention cohort enrolled during 1 February to 15 May 2010 received LRUTF. Subjects receiving either of the two therapeutic foods were temporally separated to minimize the spillover effect. The study subjects and the technician delegated for measuring weight was blinded for type of intervention.
Rate of weight-gain/kg/day.
There were 49 subjects in each group. Both groups were comparable. Rate of weight-gain was found to be (9.59 ± 3.39 g/kg/d) in LRUTF group and (5.41 ± 1.05 g/kg/d) in locally prepared F100 group. Significant difference in rate of weight gain was observed in LRUTF group (P<0.0001; 95% CI 3.17-5.19). No serious adverse effect was observed with use of LRUTF.
LRUTF promotes more rapid weight-gain when compared with F100 in patients with severe acute malnutrition during rehabilitation phase.
比较在医院康复阶段，本地制备的即食治疗食品（LRUTF）和本地制备的 F100 饮食在促进严重急性营养不良儿童体重增加方面的疗效。
非随机对照试验。
印度中部三级保健公立医院儿科病房。
2009 年 10 月 1 日至 2010 年 5 月 30 日。
6 至 60 个月大，在研究期间被诊断为严重急性营养不良并住院的儿童。
随机分组，选择干预组和对照组。对照组于 2009 年 10 月 1 日至 1 月 31 日入组，接受 F100；干预组于 2 月 1 日至 5 月 15 日入组，接受 LRUTF。接受两种治疗食品中的任何一种的受试者都被暂时分开，以尽量减少溢出效应。研究对象和负责测量体重的技术人员对干预类型均不知情。
体重增加速度（kg/天）。
每组各有 49 名受试者。两组具有可比性。LRUTF 组体重增加速度为（9.59 ± 3.39 g/kg/d），本地制备的 F100 组为（5.41 ± 1.05 g/kg/d）。LRUTF 组体重增加速度显著高于 F100 组（P<0.0001；95%CI 3.17-5.19）。使用 LRUTF 未观察到严重不良事件。
在严重急性营养不良患者的康复阶段，LRUTF 比 F100 更能促进体重快速增加。
