Liu Jin, Zhu Caigang, Jiang Jingying, Xu Kexin
State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, Tianjin, China.
These authors contributed equally to this work.
Biomed Opt Express. 2018 Nov 2;9(12):5903-5914. doi: 10.1364/BOE.9.005903. eCollection 2018 Dec 1.
We report a novel approach for the accurate measurement of glucose absorption in turbid media using a spectrally resolved reflectance setup. Our proposed reflectance setup with specialized variable source-detector separations enables scattering-independent absorption measurement, which is critical to long-term glucose concentration monitoring. Starting from the first-order approximation of the radiative transfer equation (RTE), we developed a scattering-independent glucose absorption measurement method and then evaluated this approach by Monte Carlo simulations as well as tissue-mimicking phantom studies in which glucose concentration was accurately measured. Our study demonstrates the potential of our proposed scattering-independent absorption measurement technique as an effective tool to quantify glucose levels in turbid media, which is an important step towards future long-term glucose concentration monitoring in human subjects.
我们报告了一种使用光谱分辨反射率设置精确测量混浊介质中葡萄糖吸收的新方法。我们提出的具有专门可变源 - 探测器间距的反射率设置能够进行与散射无关的吸收测量，这对于长期葡萄糖浓度监测至关重要。从辐射传输方程（RTE）的一阶近似出发，我们开发了一种与散射无关的葡萄糖吸收测量方法，然后通过蒙特卡罗模拟以及组织模拟体模研究对该方法进行了评估，在这些研究中准确测量了葡萄糖浓度。我们的研究证明了我们提出的与散射无关的吸收测量技术作为量化混浊介质中葡萄糖水平的有效工具的潜力，这是朝着未来在人体中进行长期葡萄糖浓度监测迈出的重要一步。
