Internal Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
Curr Oncol Rep. 2019 May 7;21(7):56. doi: 10.1007/s11912-019-0806-2.
The purpose of this review is to examine the latest research and data on the use of immunotherapy in older adults with cancer in order to identify key gaps in the literature for future research.
Immune checkpoint inhibitors are gaining approval and being incorporated into routine clinical use for numerous malignancies across age groups due to their overall efficacy and favorable side effect profiles. Although immune checkpoint inhibitors appear both safe and effective in older adults, deliberate study of immunotherapies in older adults is highly warranted given the paucity of data in a population with unique immunobiology that comprises the majority of the cancer population worldwide.
本综述旨在研究免疫疗法在老年癌症患者中的最新研究和数据，以确定未来研究的文献中的关键空白。
由于免疫检查点抑制剂的总体疗效和良好的副作用特征，它们在不同年龄段的多种恶性肿瘤中的批准和常规临床应用正在增加。尽管免疫检查点抑制剂在老年人中似乎既安全又有效，但鉴于在全球癌症患者中占大多数的具有独特免疫生物学特性的人群中数据稀缺，非常有必要对老年人的免疫疗法进行深入研究。
