Eison M S
Neuropsychobiology. 1986;16(1):15-8. doi: 10.1159/000118291.
Failure to gain weight during withdrawal from chronic regimens of dependence-producing drugs is observed in laboratory rats. Withdrawal from the benzodiazepine anxiolytic agent diazepam, whether induced by cessation of treatment or precipitated by administration of the specific benzodiazepine antagonist Ro-15,1788, is accompanied by weight loss. However, the same withdrawal treatments following a chronic regimen of equal doses of the nonbenzodiazepine antianxiety drug buspirone are not associated with weight loss. Buspirone-treated rats gain weight during withdrawal, suggesting that this novel anxiolytic should lack dependence liability in man.
在实验大鼠中观察到，从产生依赖性的药物慢性给药方案中撤药期间体重未能增加。从苯二氮䓬类抗焦虑药地西泮撤药时，无论是通过停止治疗诱导还是通过给予特异性苯二氮䓬拮抗剂Ro-15,1788促发，都会伴有体重减轻。然而，在给予等量非苯二氮䓬类抗焦虑药丁螺环酮的慢性给药方案后进行相同的撤药处理，并未出现体重减轻。用丁螺环酮治疗的大鼠在撤药期间体重增加，这表明这种新型抗焦虑药在人类中应无成瘾倾向。
