Department of Infectious Disease, People's Hosptial of Rizhao, Affiliated Clinical Hospital of Jining Medical Univerity, Jining Medical University, Rizhao, Shandong, China (mainland).
Department of Digestive Disease, People's Hosptial of Rizhao, Affiliated Clinical Hospital of Jining Medical Univerity, Jining Medical University, Rizhao, Shandong, China (mainland).
Med Sci Monit. 2019 May 9;25:3417-3424. doi: 10.12659/MSM.913705.
BACKGROUND Nowadays, more than 170 million patients suffer from diabetes mellitus worldwide. This study aimed to investigate the effects of sleeve gastrectomy (SG) and ileal transposition (IT) surgery on the control of diabetes. MATERIAL AND METHODS Goto-Kakizaki rats were used to establish type 2 diabetes models and undergo SG or IT surgery. At 2 months post-surgery, insulin, glucose, triglycerides (TG), total cholesterol (TC), glucose tolerance, glucagon-like peptide-1 (GLP-1) levels, and insulin sensitivity were evaluated. RESULTS SG significantly shortened operative time and post-operative recovery time compared to IT surgery (P<0.05). SG and IT surgery resulted in significantly induced weight loss, significantly decreased levels of glucose, and significantly enhanced levels of Ghrelin compared the Sham surgery group (P<0.001). SG and IT surgery resulted in significantly increased GLP-1 levels compared to Sham surgery (P<0.001). SG resulted in better reduction of oral glucose tolerance test (OGTT) glucose compared to IT surgery (P<0.05). SG and IT surgery significantly upregulated insulin tolerance test (ITT) levels compared to Sham surgery (P<0.001). SG induced better reductions in TC and TG compared to IT surgery (P<0.05). CONCLUSIONS In non-obese rats with spontaneous diabetes, both SG and IT surgery were found to control diabetes by regulating body weight and levels of glucose, Ghrelin, GLP-1, OGTT glucose, insulin, TC, and TG. Moreover, SG demonstrated advantages of shorter operative time, shorter post-operative recovery time, and better control of diabetes compared to IT surgery.
目前，全世界有超过 1.7 亿糖尿病患者。本研究旨在探讨袖状胃切除术（SG）和回肠转位术（IT）对糖尿病控制的影响。
使用 Goto-Kakizaki 大鼠建立 2 型糖尿病模型，并进行 SG 或 IT 手术。术后 2 个月，评估胰岛素、血糖、甘油三酯（TG）、总胆固醇（TC）、葡萄糖耐量、胰高血糖素样肽-1（GLP-1）水平和胰岛素敏感性。
与 IT 手术相比，SG 显著缩短了手术时间和术后恢复时间（P<0.05）。SG 和 IT 手术均显著诱导体重减轻，显著降低血糖水平，显著增加 Ghrelin 水平与 Sham 手术组相比（P<0.001）。SG 和 IT 手术与 Sham 手术相比，GLP-1 水平显著升高（P<0.001）。SG 导致 OGTT 葡萄糖的降低优于 IT 手术（P<0.05）。SG 和 IT 手术与 Sham 手术相比，ITT 水平显著升高（P<0.001）。SG 诱导的 TC 和 TG 降低优于 IT 手术（P<0.05）。
在自发性糖尿病的非肥胖大鼠中，SG 和 IT 手术均通过调节体重和血糖、Ghrelin、GLP-1、OGTT 葡萄糖、胰岛素、TC 和 TG 水平来控制糖尿病。此外，与 IT 手术相比，SG 具有手术时间更短、术后恢复时间更短、糖尿病控制更好的优势。
