de Bona Castelan João, Bettiol Jane, d'Acampora Armando José, Castelan João Vicente Edom, de Souza Jonathan Caon, Bressiani Vinicius, Giroldi Simone Batisti
Departamento de Medicina e Laboratório de Imunologia da Universidade do Extremo Sul Catarinense (Unesc), Criciúma, SC, Brazil.
Obes Surg. 2007 Jul;17(7):957-61. doi: 10.1007/s11695-007-9150-y.
Sleeve gastrectomy (SG) has been used for the surgical treatment of morbid obesity, as a first step or as a definitive treatment. The objective of this pilot study was to establish an animal model for SG in Wistar rats.
12 male Wistar rats were operated on. 8 of them underwent a SG, with a hand-sewn invaginating suture, and 4 underwent a laparotomy and stomach manipulation (control group). Sterilized materials, prophylactic antibiotics and nutritional supplementation were used. The animals' weight was checked on the operation day and on a weekly basis, for 7 weeks.
The experimental SG model was possible due to careful procedures in the pre- and postoperative period. The average weight loss in the sleeve gastrectomy group was 49.6 g (43 to 60 g) until the 4th week, whereas in the control group average weight loss was 15 g (10 to 25 g) but the weight loss was achieved in the 1st week. After the 7th week, there was weight gain in both groups. However, in the SG group, this gain was significantly lower than in the control group.
It has been possible to obtain a SG experimental model. The effects of this SG appear to be beneficial in weight loss. Biochemical and molecular mechanisms may also be investigated based on this model.
袖状胃切除术（SG）已被用于病态肥胖的外科治疗，作为第一步治疗或确定性治疗。本初步研究的目的是建立Wistar大鼠的袖状胃切除术动物模型。
对12只雄性Wistar大鼠进行手术。其中8只接受袖状胃切除术，采用手工缝合内翻缝合，4只接受剖腹术和胃操作（对照组）。使用了消毒材料、预防性抗生素和营养补充剂。在手术当天和每周检查动物体重，持续7周。
由于术前和术后的仔细操作，实验性袖状胃切除术模型得以建立。袖状胃切除术组直到第4周的平均体重减轻为49.6克（43至60克），而对照组的平均体重减轻为15克（10至25克），但体重减轻在第1周就实现了。第7周后，两组体重均增加。然而，袖状胃切除术组的体重增加明显低于对照组。
已成功获得袖状胃切除术实验模型。该袖状胃切除术的效果似乎对体重减轻有益。基于此模型还可研究生化和分子机制。
