• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

糖皮质激素作用于室管膜胶质细胞并抑制脊髓损伤修复。

Glucocorticoids Target Ependymal Glia and Inhibit Repair of the Injured Spinal Cord.

作者信息

Nelson Craig M, Lennon Vanda A, Lee Han, Krug Randall G, Kamalova Aichurok, Madigan Nicolas N, Clark Karl J, Windebank Anthony J, Henley John R

机构信息

Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United States.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States.

出版信息

Front Cell Dev Biol. 2019 Apr 24;7:56. doi: 10.3389/fcell.2019.00056. eCollection 2019.

DOI:10.3389/fcell.2019.00056
PMID:31069223
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6491705/
Abstract

Following injury, the mammalian spinal cord forms a glial scar and fails to regenerate. In contrast, vertebrate fish spinal cord tissue regenerates significantly to restore function. Cord transection in zebrafish () initially causes paralysis and neural cell death. Subsequently, ependymal glia proliferate, bipolar glia extend across the lesion, and new neurons are born; axons from spared and nascent neurons extend along -lesional glial bridges to restore functional connectivity. Here we report that glucocorticoids, used in the clinical management of spinal cord injury, directly inhibit neural repair by targeting ependymal glia independently of hematogenous cells and microglia. After transecting injury, the glucocorticoid receptor in ependymal glia is regulated differentially in zebrafish (becoming inactive) vs. the rat (becoming active). Glucocorticoid blockade of neural regeneration via a direct effect on ependymal glia has important therapeutic implications for the putative benefit of corticosteroids in early management of spinal cord injury.

摘要

受伤后，哺乳动物的脊髓会形成胶质瘢痕且无法再生。相比之下，脊椎动物鱼类的脊髓组织能显著再生以恢复功能。斑马鱼的脊髓横断最初会导致瘫痪和神经细胞死亡。随后，室管膜胶质细胞增殖，双极胶质细胞跨越损伤部位延伸，新的神经元生成； spared和新生神经元的轴突沿着损伤部位的胶质桥延伸以恢复功能连接。我们在此报告，用于脊髓损伤临床治疗的糖皮质激素通过独立于造血细胞和小胶质细胞靶向室管膜胶质细胞直接抑制神经修复。横断损伤后，斑马鱼（变得不活跃）与大鼠（变得活跃）的室管膜胶质细胞中的糖皮质激素受体受到不同调节。糖皮质激素通过对室管膜胶质细胞的直接作用阻断神经再生，这对于皮质类固醇在脊髓损伤早期治疗中的假定益处具有重要的治疗意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/56abf348f928/fcell-07-00056-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/da0d0c4fc888/fcell-07-00056-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/0cdcfb8479b7/fcell-07-00056-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/6c304b91890d/fcell-07-00056-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/6cb152a66fe8/fcell-07-00056-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/c300b3a10843/fcell-07-00056-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/0ebbce086d4c/fcell-07-00056-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/e96da39cd5af/fcell-07-00056-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/39ac987ca2c2/fcell-07-00056-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/56abf348f928/fcell-07-00056-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/da0d0c4fc888/fcell-07-00056-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/0cdcfb8479b7/fcell-07-00056-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/6c304b91890d/fcell-07-00056-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/6cb152a66fe8/fcell-07-00056-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/c300b3a10843/fcell-07-00056-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/0ebbce086d4c/fcell-07-00056-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/e96da39cd5af/fcell-07-00056-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/39ac987ca2c2/fcell-07-00056-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4871/6491705/56abf348f928/fcell-07-00056-g009.jpg

相似文献

1
Glucocorticoids Target Ependymal Glia and Inhibit Repair of the Injured Spinal Cord.糖皮质激素作用于室管膜胶质细胞并抑制脊髓损伤修复。
Front Cell Dev Biol. 2019 Apr 24;7:56. doi: 10.3389/fcell.2019.00056. eCollection 2019.
2
Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish.Foxj1a 在室管膜前体细胞中表达，控制中央管的位置，并在斑马鱼再生过程中激活新的室管膜细胞。
Open Biol. 2017 Nov;7(11). doi: 10.1098/rsob.170139.
3
Cells in the adult human spinal cord ependymal region do not proliferate after injury.成年人大脊髓室管膜区的细胞在损伤后不会增殖。
J Pathol. 2018 Dec;246(4):415-421. doi: 10.1002/path.5151. Epub 2018 Oct 30.
4
The spinal ependymal zone as a source of endogenous repair cells across vertebrates.脊椎室管膜区作为脊椎动物内源性修复细胞的来源。
Prog Neurobiol. 2018 Nov;170:67-80. doi: 10.1016/j.pneurobio.2018.04.002. Epub 2018 Apr 9.
5
Connexin Signaling Is Involved in the Reactivation of a Latent Stem Cell Niche after Spinal Cord Injury.缝隙连接信号在脊髓损伤后潜伏干细胞龛的再激活中起作用。
J Neurosci. 2020 Mar 11;40(11):2246-2258. doi: 10.1523/JNEUROSCI.2056-19.2020. Epub 2020 Jan 30.
6
Spinal cord regeneration: a phenomenon unique to urodeles?脊髓再生：有尾两栖类特有的现象？
Int J Dev Biol. 1996 Aug;40(4):823-31.
7
Electron microscopic study of the progeny of ependymal stem cells in the normal and injured spinal cord.正常和损伤脊髓室管膜干细胞子代的电子显微镜研究
Surg Neurol. 2005;64 Suppl 2:S28-32. doi: 10.1016/j.surneu.2005.07.057.
8
Syntenin-a promotes spinal cord regeneration following injury in adult zebrafish.Syntenin-a 促进成年斑马鱼损伤后的脊髓再生。
Eur J Neurosci. 2013 Jul;38(2):2280-9. doi: 10.1111/ejn.12222. Epub 2013 Apr 22.
9
Embryonic radial glia bridge spinal cord lesions and promote functional recovery following spinal cord injury.胚胎放射状胶质细胞可桥接脊髓损伤部位并促进脊髓损伤后的功能恢复。
Exp Neurol. 2005 Jun;193(2):394-410. doi: 10.1016/j.expneurol.2004.12.024.
10
Synaptic regeneration and glial reactions in the transected spinal cord of the lamprey.七鳃鳗横断脊髓中的突触再生与神经胶质反应
J Neurocytol. 1981 Feb;10(1):57-79. doi: 10.1007/BF01181745.

引用本文的文献

1
Animal Models of Spinal Cord Injury.脊髓损伤的动物模型
Biomedicines. 2025 Jun 10;13(6):1427. doi: 10.3390/biomedicines13061427.
2
Wnt signaling pathway in spinal cord injury: from mechanisms to potential applications.脊髓损伤中的Wnt信号通路：从机制到潜在应用
Front Mol Neurosci. 2024 Jul 24;17:1427054. doi: 10.3389/fnmol.2024.1427054. eCollection 2024.
3
Inflammation is a critical factor for successful regeneration of the adult zebrafish retina in response to diffuse light lesion.炎症是成年斑马鱼视网膜在受到漫射光损伤后成功再生的关键因素。

本文引用的文献

1
Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration.巨噬细胞在斑马鱼脊髓再生中对促炎细胞因子 Il-1β 和 Tnf-α 的动态调控。
Nat Commun. 2018 Nov 7;9(1):4670. doi: 10.1038/s41467-018-07036-w.
2
Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish.Wnt信号通路在斑马鱼功能性脊髓再生中控制促再生的胶原蛋白XII。
Nat Commun. 2017 Jul 25;8(1):126. doi: 10.1038/s41467-017-00143-0.
3
Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish.
Front Cell Dev Biol. 2024 Jul 12;12:1332347. doi: 10.3389/fcell.2024.1332347. eCollection 2024.
4
Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment.富含亮氨酸的小蛋白聚糖通过改变损伤环境的结构和力学特性来抑制中枢神经系统的再生。
Nat Commun. 2023 Oct 26;14(1):6814. doi: 10.1038/s41467-023-42339-7.
5
Transactivation Response DNA-Binding Protein of 43 (TDP-43) and Glial Cell Roles in Neurological Disorders.43 kDa反式激活反应DNA结合蛋白（TDP-43）与神经疾病中的胶质细胞作用
Cureus. 2022 Oct 24;14(10):e30639. doi: 10.7759/cureus.30639. eCollection 2022 Oct.
6
Unique advantages of zebrafish larvae as a model for spinal cord regeneration.斑马鱼幼体作为脊髓再生模型的独特优势。
Front Mol Neurosci. 2022 Sep 7;15:983336. doi: 10.3389/fnmol.2022.983336. eCollection 2022.
7
Ependymal and Neural Stem Cells of Adult Molly Fish (, Valenciennes, 1846) Brain: Histomorphometry, Immunohistochemical, and Ultrastructural Studies.成年莫桑比克罗非鱼（，Valenciennes，1846）脑室管膜和神经干细胞：组织形态计量学、免疫组织化学和超微结构研究。
Cells. 2022 Aug 27;11(17):2659. doi: 10.3390/cells11172659.
8
Uncovering the spectrum of adult zebrafish neural stem cell cycle regulators.揭示成年斑马鱼神经干细胞周期调节因子的谱系
Front Cell Dev Biol. 2022 Jun 29;10:941893. doi: 10.3389/fcell.2022.941893. eCollection 2022.
9
Enhancer selection dictates gene expression responses in remote organs during tissue regeneration.增强子选择决定了组织再生过程中远程器官的基因表达反应。
Nat Cell Biol. 2022 May;24(5):685-696. doi: 10.1038/s41556-022-00906-y. Epub 2022 May 5.
10
Dynamic Diversity of Glial Response Among Species in Spinal Cord Injury.脊髓损伤中不同物种间神经胶质反应的动态多样性
Front Aging Neurosci. 2021 Nov 26;13:769548. doi: 10.3389/fnagi.2021.769548. eCollection 2021.
损伤诱导的ctgfa指导斑马鱼的神经胶质桥接和脊髓再生。
Science. 2016 Nov 4;354(6312):630-634. doi: 10.1126/science.aaf2679.
4
Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification.克洛什（Cloche）是一个 bHLH-PAS 转录因子，它驱动造血血管的特化。
Nature. 2016 Jul 14;535(7611):294-8. doi: 10.1038/nature18614.
5
Astrocyte scar formation aids central nervous system axon regeneration.星形胶质细胞瘢痕形成有助于中枢神经系统轴突再生。
Nature. 2016 Apr 14;532(7598):195-200. doi: 10.1038/nature17623. Epub 2016 Mar 30.
6
Spinal motor neurons are regenerated after mechanical lesion and genetic ablation in larval zebrafish.在幼体斑马鱼中，脊髓运动神经元在机械损伤和基因消融后会再生。
Development. 2016 May 1;143(9):1464-74. doi: 10.1242/dev.129155. Epub 2016 Mar 10.
7
Characterization of Proliferating Neural Progenitors after Spinal Cord Injury in Adult Zebrafish.成年斑马鱼脊髓损伤后增殖神经祖细胞的特征分析
PLoS One. 2015 Dec 2;10(12):e0143595. doi: 10.1371/journal.pone.0143595. eCollection 2015.
8
Activation of glucocorticoid receptors in Müller glia is protective to retinal neurons and suppresses microglial reactivity.米勒胶质细胞中糖皮质激素受体的激活对视网膜神经元具有保护作用，并可抑制小胶质细胞的反应性。
Exp Neurol. 2015 Nov;273:114-25. doi: 10.1016/j.expneurol.2015.08.007. Epub 2015 Aug 10.
9
Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart.早期糖皮质激素活性的扰动会影响成年斑马鱼（Danio rerio）心脏的结构、功能和分子组成。
Mol Cell Endocrinol. 2015 Oct 15;414:120-31. doi: 10.1016/j.mce.2015.07.025. Epub 2015 Jul 26.
10
A diffusible signal derived from hematopoietic cells supports the survival and proliferation of regenerative cells during zebrafish fin fold regeneration.源自造血细胞的一种可扩散信号在斑马鱼鳍褶再生过程中支持再生细胞的存活和增殖。
Dev Biol. 2015 Mar 1;399(1):80-90. doi: 10.1016/j.ydbio.2014.12.015. Epub 2014 Dec 19.