Brunel Center for Advanced Solidification Technology (BCAST), Institute of Materials and Manufacturing, Brunel University London, Uxbridge, London UB8 3PH, UK.
Biomater Sci. 2019 May 28;7(6):2241-2263. doi: 10.1039/c9bm00289h.
Despite the high potential of biodegradable magnesium (Mg) alloys as a new generation of biomaterials for orthopaedic and cardiovascular implantation, their high corrosion rate in body fluid limits their suitability for clinical applications. Extensive research has been performed to improve the corrosion resistance of Mg-based biomaterials. Researchers have also been working to develop new testing and assessment techniques to evaluate the corrosion performance and other in vitro and in vivo properties of their modified Mg alloys. The objective of this review is to present the principles and operation procedures of commonly used standard methods for assessment of Mg-based biomaterials from bench to clinic. The pros and cons of each of these methods are discussed, together with factors for consideration to choose the right methodology. This review also presents the current state and challenges in understanding the testing of Mg-based biomaterials.
尽管可生物降解的镁 (Mg) 合金作为新一代用于骨科和心血管植入物的生物材料具有很高的潜力，但它们在体液中的高腐蚀率限制了它们在临床应用中的适用性。已经进行了广泛的研究来提高基于 Mg 的生物材料的耐腐蚀性。研究人员还致力于开发新的测试和评估技术，以评估其改性 Mg 合金的腐蚀性能以及其他体外和体内性能。本综述的目的是介绍从实验室到临床评估基于 Mg 的生物材料的常用标准方法的原理和操作程序。讨论了这些方法中的每一种的优缺点，以及选择正确方法的考虑因素。本综述还介绍了理解 Mg 基生物材料测试的现状和挑战。
