Burke W H
Poult Sci. 1987 Jan;66(1):147-53. doi: 10.3382/ps.0660147.
Thyrotropin-releasing hormone (TRH) was administered continuously or intermittently in the drinking water of male broiler chickens from 2 to 21 days of age. Intermittent administration of TRH was accomplished by giving birds access to the solution for 2 hr, then removing it for 2 hr, with six repetitions of this procedure each 24 hr. The TRH concentration was such that the birds each would ingest 10 to 20 micrograms of the material during each 2-hr period that it was available. Plasma growth hormone (GH) levels were elevated within 30 min after an episode of TRH administration at 2, 7, and 14 days of age but not at 21 days. Continuous administration of TRH had no effect on GH in plasma at any age. Thyroxine concentrations in plasma were increased within 30 min of first exposure to TRH at 2 days of age, but they were unaffected by intermittent episodes of TRH at 7, 14, and 21 days of age. Triiodothyronine concentrations in plasma were unaffected by TRH at any age. Even though intermittent TRH administration elicited significant elevation in plasma GH for at least 14 days of the experiment, it had no effect on body weight, feed consumption, or weight of the gastrocnemius muscle, the pectoralis major muscle, liver, tibia, or abdominal fat pad.
在2至21日龄的雄性肉鸡饮水中持续或间歇性给予促甲状腺激素释放激素（TRH）。TRH的间歇性给药是通过让鸡只接触该溶液2小时，然后移除2小时来完成的，每24小时重复此过程6次。TRH的浓度应使每只鸡在其可获取该物质的每个2小时期间摄入10至20微克。在2日龄、7日龄和14日龄时，TRH给药后30分钟内血浆生长激素（GH）水平升高，但在21日龄时未升高。在任何年龄，持续给予TRH对血浆中的GH均无影响。在2日龄首次接触TRH后30分钟内，血浆甲状腺素浓度升高，但在7日龄、14日龄和21日龄时，TRH的间歇性给药对其无影响。在任何年龄，TRH对血浆三碘甲状腺原氨酸浓度均无影响。尽管在实验至少14天的时间里，间歇性给予TRH会引起血浆GH显著升高，但对体重、采食量、腓肠肌、胸大肌、肝脏、胫骨或腹部脂肪垫的重量均无影响。
