Department of Cardiology, Shanxi Cardiovascular Hospital, 18 Yifen street, Taiyuan, 030024, Shanxi, China.
Heart Fail Rev. 2019 Nov;24(6):941-948. doi: 10.1007/s10741-019-09800-6.
Heart failure is the end stage of various heart diseases such as ischemic heart disease, dilated cardiomyopathy, valvular heart disease, congenital heart disease, and hypertensive myocardial damage. It is characterized by a decrease in myocardial contractility, but there is currently no ideal treatment. Nitroxyl hydrogen (HNO) is considered to be a protonated form of NO. It has special chemical properties compared to other nitrogen oxides. In the body of organisms, HNO can participate in all aspects of the occurrence and development of heart failure (HF) and react with some proteins closely related to cardiac activity, changing its spatial structure and exerting cardioprotective effects. In recent years, studies have shown that HNO can inhibit cardiomyocyte hypertrophy, reduce inflammation, enhance myocardial contractility, dilate coronary arteries as well as peripheral blood vessels in early heart failure, and protect the heart against heart failure. This paper, combined with the latest research results at home and abroad, clarifies that nitrosyl hydrogen exerts cardioprotective effects through various processes that occur in the development of heart failure.
心力衰竭是缺血性心脏病、扩张型心肌病、瓣膜性心脏病、先天性心脏病和高血压性心肌损伤等各种心脏病的终末期。其特征是心肌收缩力下降，但目前尚无理想的治疗方法。亚硝酰氢（HNO）被认为是 NO 的质子化形式。与其他氮氧化物相比，它具有特殊的化学性质。在生物体内，HNO 可以参与心力衰竭（HF）的发生和发展的各个方面，并与一些与心脏活动密切相关的蛋白质发生反应，改变其空间结构并发挥心脏保护作用。近年来的研究表明，HNO 可以抑制心肌细胞肥大、减轻炎症、增强心肌收缩力、扩张早期心力衰竭时的冠状动脉和外周血管，并保护心脏免受心力衰竭的影响。本文结合国内外最新研究成果，阐明了亚硝酰氢通过心力衰竭发展过程中发生的各种过程发挥心脏保护作用。
