使用双环糊精修饰的胶束电动色谱法对选定咪唑类药物进行对映体拆分。

Enantioseparation of Selected Imidazole Drugs Using Dual Cyclodextrin-Modified Micellar Electrokinetic Chromatography.

作者信息

Ibrahim Wan Aini Wan, Wahib Siti Munirah Abd, Hermawan Dadan, Sanagi Mohd Marsin

机构信息

Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia.

Faculty of Mathematics and Natural Sciences, Department of Chemistry, Universitas Jenderal Soedirman, Purwokerto, Indonesia.

出版信息

Methods Mol Biol. 2019;1985:407-416. doi: 10.1007/978-1-4939-9438-0_24.

DOI:10.1007/978-1-4939-9438-0_24

PMID:31069749

Abstract

Particular attention has been paid to capillary electrophoresis as versatile and environmentally friendly approach for enantioseparations of a wide spectrum of compounds. Cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) is a method of choice to provide effective separation toward hydrophobic and uncharged stereoisomers. The chiral discrimination of the solutes relies upon the partitioning between a given CD in the aqueous phase and micelles formed from a surfactant. Synergistic combinations of chiral selectors, surfactant, and modifier contribute to successful enantioseparations of the enantiomers. In this chapter, an application of CD-MEKC for the enantioseparation of selected imidazole drugs employing a dual CDs system is described.

摘要

毛细管电泳作为一种用于多种化合物对映体分离的通用且环境友好的方法，已受到特别关注。环糊精修饰的胶束电动色谱法（CD-MEKC）是对疏水和不带电立体异构体进行有效分离的首选方法。溶质的手性识别依赖于给定环糊精在水相和由表面活性剂形成的胶束之间的分配。手性选择剂、表面活性剂和改性剂的协同组合有助于对映体的成功对映体分离。在本章中，描述了使用双环糊精系统的CD-MEKC在选定咪唑类药物对映体分离中的应用。