用于对映体分离的环糊精修饰胶束电动色谱法。

Cyclodextrin-modified micellar electrokinetic chromatography for enantioseparations.

作者信息

Ibrahim Wan Aini Wan, Hermawan Dadan, Sanagi Mohd Marsin

机构信息

Separation Science and Technology Group (SepSTec), Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Johor, Malaysia.

出版信息

Methods Mol Biol. 2013;970:349-61. doi: 10.1007/978-1-62703-263-6_22.

DOI:10.1007/978-1-62703-263-6_22

PMID:23283789

Abstract

The separation of enantiomers is one of the important fields of modern analytical chemistry, especially for agrochemical and pharmaceutical products because the stereochemistry has a significant influence on the biological activities of compounds. Cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) has become an important capillary electrophoresis mode for enantioseparations. Here, we describe an example of a CD-MEKC method using hydroxypropyl-γ-cyclodextrin as chiral selector and sodium dodecyl sulfate as micellar solution for enantioseparation of triazole fungicides and the drug econazole.

摘要

对映体的分离是现代分析化学的重要领域之一，特别是对于农用化学品和医药产品而言，因为立体化学对化合物的生物活性有重大影响。环糊精修饰的胶束电动色谱法（CD-MEKC）已成为对映体分离的一种重要毛细管电泳模式。在此，我们描述了一个CD-MEKC方法的实例，该方法使用羟丙基-γ-环糊精作为手性选择剂，十二烷基硫酸钠作为胶束溶液，用于三唑类杀菌剂和药物益康唑的对映体分离。