Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Cd. Universitaria, Coyoacán04510, Cd. Mx., Mexico.
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Av. de las Ciencias S/N, Juriquilla, 76230, Querétaro, Mexico.
Z Naturforsch C J Biosci. 2020 Dec 10;76(5-6):251-255. doi: 10.1515/znc-2020-0265. Print 2021 May 26.
Chemical investigation of the aerial parts (except fruits) of the medicinal, hallucinogen and toxic plant Mill. [Solanaceae] led to the isolation of the new withanolide, dinnoxolide A (), along with the known compounds 21,27-dihydroxy-1-oxowitha-2,5,24-trienolide (), daturamalakin B () and withametelin (). Their structures were established by analysis of their spectroscopic data, including 1D and 2D NMR experiments and MS. Compounds and were isolated as natural products for the first time and the name dinnoxolide B was given to compound . The four withanolides showed cytotoxic activity against U251 (glioblastoma) and SK-LU-1 (lung adenocarcinoma) human cancer cell lines, with IC values ranging from 1.2 to 19.6 µM, and also against the noncancerous monkey kidney cell line (COS-7), with IC values ranging from 5.0 to 19.7 µM. Compound was two times more active than the reference compound, etoposide, against lung adenocarcinoma cells.
药用、致幻和有毒植物 Mill. [茄科] 的地上部分（果实除外）的化学研究导致了新的颠茄烷内酯，dinnoxolide A () 的分离，以及已知化合物 21,27-二羟基-1-氧代-2,5,24-三烯醇内酯 ()、daturamalakin B () 和 withametelin ()。它们的结构通过分析其光谱数据，包括 1D 和 2D NMR 实验和 MS 确定。化合物 和 作为天然产物首次被分离出来，化合物 被命名为 dinnoxolide B。四种颠茄烷内酯对 U251（神经胶质瘤）和 SK-LU-1（肺腺癌）人癌细胞系表现出细胞毒性活性，IC 值范围为 1.2 至 19.6 μM，对非癌细胞系（COS-7）也表现出活性，IC 值范围为 5.0 至 19.7 μM。化合物 对肺腺癌细胞的活性比参考化合物依托泊苷高两倍。
