College of Food Science and Engineering, Northwest A&F University, Yangling, China.
College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, China.
Foodborne Pathog Dis. 2019 Oct;16(10):671-678. doi: 10.1089/fpd.2018.2591. Epub 2019 May 9.
is a halophilic Gram-negative foodborne pathogen that is widely distributed in marine environments. It can cause acute gastroenteritis and other diseases. This study aimed to investigate the antivirulence activity of thymoquinone (TQ) on . . TQ was shown to effectively inhibit . Subminimum inhibitory concentrations of TQ inhibited swimming and swarming motility, quorum sensing, biofilm formation, the ability of to adhere and invade the host cells, and the expression of virulence-associated genes of . . These findings suggest that TQ can effectively inhibit the growth of . and significantly reduce its pathogenicity. Considering its safety and various biological activities, TQ has the potential to be developed as a natural antibacterial substance to reduce the diseases associated with . .
是一种嗜盐、革兰氏阴性的食源性致病菌，广泛分布于海洋环境中。它可以引起急性肠胃炎等疾病。本研究旨在探讨百里醌（TQ）对 的抗毒力活性。结果表明，TQ 能有效抑制 的生长。TQ 的最低抑菌浓度能抑制泳动和群集运动、群体感应、生物膜形成、 黏附和侵袭宿主细胞的能力，以及 相关毒力基因的表达。这些发现表明 TQ 能有效抑制 的生长，并显著降低其致病性。考虑到其安全性和多种生物学活性，TQ 有可能被开发为一种天然抗菌物质，以减少与 相关的疾病。
