Ferguson D J, Hutchison W M
Virchows Arch A Pathol Anat Histopathol. 1987;411(1):39-43. doi: 10.1007/BF00734512.
The host parasite relationship in the brains of asymptomatic mice chronically infected with Toxoplasma gondii was examined at 3, 6 and 12 months post-infection (PI) using electron microscopy. The parasites were located in large numbers within tissue cysts which ranged in size from 10-50 microns in diameter. The cysts were predominantly found in the grey matter. The toxoplasms were enclosed by a cyst wall consisting of a membrane, with irregular invaginations, and an underlying layer of homogeneous osmiophilic material. A detailed examination of 50 cysts revealed that all the cysts were present within intact host cells irrespective of their size or the period PI. The majority of host cells could be positively identified as neurons by the presence of synapses. No extracellular cysts were observed. It is probable that the intracellular location of the cysts protects them from recognition and attack by the host immune system.
利用电子显微镜，在感染弓形虫的无症状小鼠大脑中，于感染后3个月、6个月和12个月对宿主与寄生虫的关系进行了检查。大量寄生虫位于组织囊肿内，这些囊肿直径大小在10至50微米之间。囊肿主要见于灰质中。弓形虫被一层囊肿壁所包裹，该囊肿壁由具有不规则内陷的膜和一层均质嗜锇物质组成。对50个囊肿进行的详细检查显示，所有囊肿均存在于完整的宿主细胞内，无论其大小或感染后的时间长短。通过突触的存在，大多数宿主细胞可被明确鉴定为神经元。未观察到细胞外囊肿。囊肿的细胞内位置可能使其免受宿主免疫系统的识别和攻击。
