Sims T A, Hay J, Talbot I C
University Department of Pathology, Leicester Royal Infirmary, U.K.
J Pathol. 1988 Nov;156(3):255-61. doi: 10.1002/path.1711560311.
The wall of intact tissue cysts in the brains of mice with congenital toxoplasmosis was investigated using light and electron microscopy. Impregnation of the wall with reduced silver salts and protargol silver suggested that it was composed, at least in part, of components derived from the neuronal cytoskeleton. Electron microscopy extended these observations and revealed that intact cysts were separated from the extracellular compartment by a layer of neurofibrillae enclosed within the host cell membrane. It is suggested that this may be a means whereby intact Toxoplasma tissue cysts are protected from the host's immune response.
利用光学显微镜和电子显微镜对患有先天性弓形虫病的小鼠大脑中完整组织囊肿的壁进行了研究。用还原银盐和蛋白银对囊肿壁进行浸染显示，其至少部分由源自神经元细胞骨架的成分组成。电子显微镜扩展了这些观察结果，并揭示完整的囊肿通过一层被宿主细胞膜包裹的神经原纤维与细胞外间隙分隔开来。有人提出，这可能是完整的弓形虫组织囊肿免受宿主免疫反应影响的一种方式。
