1 Endoscopy Center, Northern Jiangsu People's Hospital, Clinical Medical College of Yangzhou University, Yangzhou, China.
2 National Engineering Center for Biochip at Shanghai, Shanghai, China.
Technol Cancer Res Treat. 2019 Jan 1;18:1533033819849069. doi: 10.1177/1533033819849069.
Long noncoding RNA ZEB1 antisense RNA 1 plays a vital role in tumorigenesis and metastasis. However, the role of ZEB1 antisense RNA 1 in gastric cancer remains unclear. This study aimed to investigate the expression level of ZEB1 antisense RNA 1 in gastric cancer tissues and evaluate its association with clinicopathological features and prognosis of patients with advanced gastric cancer receiving chemotherapy. The expression levels of ZEB1 antisense RNA 1 were examined in 224 pairs of gastric cancer and adjacent noncancerous tissues by quantitative real-time polymerase chain reaction. The associations between ZEB1 antisense RNA 1 expression and clinicopathological features or survival of patients with advanced gastric cancer were assessed. The results showed that the expression levels of ZEB1 antisense RNA 1 in gastric cancer tissues were significantly higher than those in the paracancerous tissues ( P < .001). Moreover, the high ZEB1 antisense RNA 1 expression was associated with tumor, nodes, and metastases stage IV ( P = .018) and loss of E-cadherin expression ( P = .033). Multivariate Cox hazards regression analysis revealed that high ZEB1 antisense RNA 1 expression was an independent risk factor for predicting poor prognosis in patients with advanced gastric cancer (hazard ratio = 1.530, 95% confidence interval, 1.052-2.224, P = .026). In conclusion, the present findings suggest that ZEB1 antisense RNA 1 is an independent prognostic factor for patients with advanced gastric cancer receiving chemotherapy.
长链非编码 RNA ZEB1 反义 RNA 1 在肿瘤发生和转移中起着至关重要的作用。然而，ZEB1 反义 RNA 1 在胃癌中的作用尚不清楚。本研究旨在探讨 ZEB1 反义 RNA 1 在胃癌组织中的表达水平，并评估其与接受化疗的晚期胃癌患者的临床病理特征和预后的关系。通过实时定量聚合酶链反应检测 224 对胃癌组织和相邻非癌组织中 ZEB1 反义 RNA 1 的表达水平。评估 ZEB1 反义 RNA 1 表达与晚期胃癌患者临床病理特征或生存的关系。结果表明，胃癌组织中 ZEB1 反义 RNA 1 的表达水平明显高于癌旁组织（P <.001）。此外，ZEB1 反义 RNA 1 高表达与肿瘤、淋巴结和转移分期 IV（P =.018）和 E-钙黏蛋白表达缺失（P =.033）有关。多因素 Cox 风险回归分析显示，ZEB1 反义 RNA 1 高表达是预测晚期胃癌患者预后不良的独立危险因素（风险比=1.530，95%置信区间，1.052-2.224，P =.026）。综上所述，本研究结果表明，ZEB1 反义 RNA 1 是接受化疗的晚期胃癌患者的独立预后因素。
