Department of Psychology, San Diego State University, San Diego, CA, USA.
San Diego State University/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Brain Imaging Behav. 2020 Oct;14(5):1731-1746. doi: 10.1007/s11682-019-00107-6.
Binge drinking is characterized by bouts of high-intensity alcohol intake and is associated with an array of health-related harms. Even though the transition from occasional impulsive to addictive alcohol use is not well understood, neurobiological models of addiction suggest that repeated cycles of intoxication and withdrawal contribute to the development of addiction in part through dysregulation of neurofunctional networks. Research on the neural sequelae associated with binge drinking is scant but resting state functional connectivity (RSFC) studies of alcohol use disorders (AUD) indicate that the development and maintenance of long-term excessive drinking may be mediated by network-level disruptions. The present study examined RSFC in young adult binge (BD) and light (LD) drinkers with seeds representing the networks subserving reward (the nucleus accumbens and caudate nucleus), salience (anterior cingulate cortex, ACC), and executive control (inferior frontal cortex, IFC). BDs exhibited enhanced connectivity between the striatal reward areas and the orbitofrontal cortex and the ACC, which is consistent with AUD studies and may be indicative of alcohol-motivated appetitive behaviors. Conversely, BDs demonstrated lower connectivity between the IFC and hippocampus which was associated with higher craving. This may indicate impaired ability to suppress unwanted thoughts and a failure to employ memory of the harmful consequences of heavy drinking in prospective plans and intentions. The observed greater connectivity of the reward/salience network and the lower prefrontal-hippocampal connectivity were associated with hazardous drinking levels indicating that dysregulation of neurofunctional networks may underlie binge drinking patterns.
binge drinking 表现为高强度的饮酒狂潮，与一系列与健康相关的危害有关。尽管从偶尔冲动到成瘾性饮酒的转变尚不清楚，但成瘾的神经生物学模型表明，反复的醉酒和戒断循环部分通过神经功能网络的失调导致成瘾的发展。关于与 binge drinking 相关的神经后果的研究很少，但酒精使用障碍（AUD）的静息态功能连接（RSFC）研究表明，长期过度饮酒的发展和维持可能是通过网络层面的破坏来介导的。本研究使用代表奖励（伏隔核和尾状核）、突显（前扣带皮层，ACC）和执行控制（额下回，IFC）网络的种子，检查了年轻成年 binge（BD）和 light（LD）饮酒者的 RSFC。BDs 表现出纹状体奖励区域与眶额皮层和 ACC 之间的连接增强，这与 AUD 研究一致，可能表明与酒精相关的食欲行为。相反，BDs 表现出 IFC 和海马体之间的连接降低，这与更高的渴望有关。这可能表明抑制不必要的想法的能力受损，并且未能在未来的计划和意图中运用对大量饮酒的有害后果的记忆。观察到的奖励/突显网络的更高连通性和前额叶-海马体的更低连通性与危险饮酒水平相关，表明神经功能网络的失调可能是 binge drinking 模式的基础。
