Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA.
Nat Rev Neurosci. 2017 Sep;18(9):547-558. doi: 10.1038/nrn.2017.74. Epub 2017 Jun 29.
The roles of the hippocampus and prefrontal cortex (PFC) in memory processing - individually or in concert - are a major topic of interest in memory research. These brain areas have distinct and complementary roles in episodic memory, and their interactions are crucial for learning and remembering events. Considerable evidence indicates that the PFC and hippocampus become coupled via oscillatory synchrony that reflects bidirectional flow of information. Furthermore, newer studies have revealed specific mechanisms whereby neural representations in the PFC and hippocampus are mediated through direct connections or through intermediary regions. These findings suggest a model of how the hippocampus and PFC, along with their intermediaries, operate as a system that uses the current context of experience to retrieve relevant memories.
海马体和前额叶皮层（PFC）在记忆处理中的作用——无论是单独作用还是协同作用——都是记忆研究中的一个主要课题。这些大脑区域在情景记忆中具有独特且互补的作用，它们的相互作用对于学习和记忆事件至关重要。大量证据表明，PFC 和海马体通过反映信息双向流动的振荡同步耦合在一起。此外，新的研究揭示了特定的机制，通过这些机制，PFC 和海马体中的神经表示可以通过直接连接或通过中间区域来介导。这些发现提出了一个模型，说明海马体和 PFC 及其中间区域如何作为一个系统运作，该系统利用当前的经验背景来检索相关记忆。
