Department of Clinical and Experimental Medicine, Unit of Neurology, University of Pisa, Pisa, Italy.
Brain Behav. 2019 Jun;9(6):e01247. doi: 10.1002/brb3.1247. Epub 2019 May 9.
To support the cognitive model of Freezing of Gait (FoG) we investigated FoG in a cohort of patients with Dementia with Lewy Bodies (DLB).
We assessed FoG frequency in 19 DLB patients compared to 19 control PD patients within 2 years from symptom onset and with at least 5 years follow-up. The two groups were matched by age and motor presentation at onset, severity of parkinsonism and disease duration. The presence and severity of FoG was identified as those with a score of 1 or greater on subitem 14 of the Unified Parkinson's Disease Rating Scale Part II (UPDRS II).
At T0, 68.4% DLB and 10.5% PD patients experienced FoG ≥1. The prevalence of FoG increased with disease progression (94.7% DLB and 47.3% PD subjects had FoG ≥1 at T5). DLB also showed a more severe FoG (FoG ≥2) than PD (21% vs. 0% at T0 and 52.6% vs. 10.5% at T5), consistently with previous studies reporting FoG prevalence in DLB.
This is the first study looking specifically at FoG in DLB, identifying it as a frequent and early feature of DLB and emphasizing the crucial role of cognitive impairment in the occurrence of this mysterious phenomenon.
为了支持冻结步态（Freezing of Gait，FoG）的认知模型，我们在一组路易体痴呆（Dementia with Lewy Bodies，DLB）患者中研究了 FoG。
我们评估了 19 名 DLB 患者和 19 名对照组帕金森病（Parkinson's Disease，PD）患者在症状出现后 2 年内的 FoG 频率，且这些患者都有至少 5 年的随访。这两组患者通过发病时的年龄和运动表现、帕金森病严重程度和疾病持续时间进行匹配。FoG 的存在和严重程度通过统一帕金森病评定量表第二部分（Unified Parkinson's Disease Rating Scale Part II，UPDRS II）的子项 14 评分≥1 来确定。
在 T0 时，68.4%的 DLB 和 10.5%的 PD 患者 FoG 评分≥1。FoG 的患病率随着疾病的进展而增加（94.7%的 DLB 和 47.3%的 PD 患者在 T5 时 FoG 评分≥1）。DLB 还表现出比 PD 更严重的 FoG（FoG≥2）（T0 时为 21%比 0%，T5 时为 52.6%比 10.5%），这与之前的研究报告一致，即 DLB 中 FoG 的患病率较高。
这是首次专门针对 DLB 中 FoG 进行的研究，确定了 FoG 是 DLB 的一种常见且早期的特征，并强调了认知障碍在这种神秘现象发生中的关键作用。
