Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY.
Center for Biomedical Imaging at the Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY.
J Neuroimaging. 2019 Jul;29(4):527-535. doi: 10.1111/jon.12625. Epub 2019 May 10.
Brain atrophy accelerates at the age of 60 in healthy individuals (HI) and at disease onset in multiple sclerosis (MS) patients. Whether there is an exacerbating effect of aging superimposed on MS-related brain atrophy is unknown. We estimated the aging effect on lateral ventricular volume (LVV) and whole brain volume (WBV) changes in MS patients.
1,982 MS patients (mean follow-up: 4.8 years) and 351 HI (mean follow-up: of 3.1 years), aged from 20 to 79 years old (yo), were collected retrospectively. Percent LVV change (PLVVC) and percent brain volume change (PBVC) on 1.5T and 3T MRI scanners (median of 3.9 scans per subject) were calculated. These were determined between all-time points and subjects were divided in six-decade age groups. MRI differences between age groups were calculated using analysis of covariance (ANCOVA).
Compared to HI, at first MRI, MS patients had significantly increased LVV in the age groups: 30-39 yo, 40-49 yo, 50-59 yo, 60-69 yo (all P < .0001), and 70-79 yo (P = .029), and decreased WBV in the age groups: 20-29 yo (P = .024), 30-39 yo (P = .031), 40-49 yo, and 50-59 yo (all P < .0001). Annualized PLVVC was significantly different between the age groups 20-59 and 60-79 yo in MS patients (P = .005) and HI (P < .0001), as was for PBVC in MS patients (P = .001), but not for HI (P = .521). There was a significant aging interaction effect in the annualized PLVVC (P = .001) between HI and MS patients, which was not observed for the annualized PBVC (P = .380).
Development of brain atrophy manifests progressively in MS patients, and occurs with a different pattern, as compared to aging HI. PLVVC increased across age in HI as compared to MS, while PBVC decreased across ages in both HI and MS.
健康个体（HI）的脑萎缩在 60 岁时加速，而多发性硬化症（MS）患者则在疾病发作时加速。是否存在衰老对 MS 相关脑萎缩的加剧作用尚不清楚。我们估计了 MS 患者的侧脑室容积（LVV）和全脑容积（WBV）变化的衰老效应。
回顾性收集了 1982 名 MS 患者（平均随访时间：4.8 年）和 351 名 HI（平均随访时间：3.1 年），年龄在 20 至 79 岁之间。在 1.5T 和 3T MRI 扫描仪上计算 LVV 变化百分比（PLVVC）和脑容积变化百分比（PBVC）（中位数为每位受试者 3.9 次扫描）。这些在所有时间点之间进行确定，并将受试者分为六个十年龄组。使用协方差分析（ANCOVA）计算年龄组之间的 MRI 差异。
与 HI 相比，在首次 MRI 检查中，MS 患者在 30-39 岁、40-49 岁、50-59 岁和 60-69 岁年龄组的 LVV 显著增加（均 P <.0001），在 70-79 岁年龄组的 LVV 也显著增加（P =.029），在 20-29 岁、30-39 岁、40-49 岁和 50-59 岁年龄组的 WBV 显著降低（均 P <.0001）。MS 患者和 HI 患者的 20-59 岁和 60-79 岁年龄组之间的年度 PLVVC 存在显著的年龄差异（P =.005）和 HI 患者之间的年度 PBVC 差异（P =.001），但 HI 患者之间无差异（P =.521）。在 HI 和 MS 患者之间，年度 PLVVC 存在显著的衰老相互作用效应（P =.001），但在年度 PBVC 中未观察到这种效应（P =.380）。
与 HI 相比，MS 患者的脑萎缩逐渐发展，表现出不同的模式。与 MS 患者相比，HI 患者的 LVV 随年龄增长而增加，而 HI 和 MS 患者的 PBVC 则随年龄增长而降低。
