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作者信息

Yu Xiaoqin, Müller Werner E G, Guo Zhiyong, Lin Wenhan, Zou Kun, Liu Zhen, Proksch Peter

机构信息

Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany; Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, People's Republic of China.

Institut für Physiologische Chemie, Universitätsmedizin der Johannes Gutenberg-University Mainz, Duesbergweg 6, 55128 Mainz, Germany.

出版信息

Fitoterapia. 2019 Jul;136:104168. doi: 10.1016/j.fitote.2019.05.007. Epub 2019 May 7.

DOI:10.1016/j.fitote.2019.05.007

PMID:31075487

Abstract

The Ascomycete fungus Aphanoascus fulvescens isolated from goose dung was investigated for its secondary metabolites, yielding five new indole alkaloids okaramines V-Z (1-5) and eleven known derivatives (6-16). Their structures were determined by 1D, 2D NMR spectra and HRMS data. Compounds 6, 8, 11 and 12 showed significant to moderate cytotoxicity against the mouse lymphoma cell line L5178Y with IC values ranging from 4.0 to 14.7 μM. Preliminary structure-activity relationships are discussed.

摘要

对从鹅粪中分离出的子囊菌黄褐暗梗丝孢菌的次生代谢产物进行了研究，从中获得了5种新的吲哚生物碱奥卡拉明V-Z（1-5）和11种已知衍生物（6-16）。通过一维、二维核磁共振光谱和高分辨质谱数据确定了它们的结构。化合物6、8、11和12对小鼠淋巴瘤细胞系L5178Y显示出显著至中等程度的细胞毒性，IC值范围为4.0至14.7μM。讨论了初步的构效关系。