a Cancer Clinical Studies Unit , Mayo Clinic , Jacksonville , FL , USA.
b Department of Medicine , Mayo Clinic , Jacksonville , FL , USA.
Expert Opin Ther Targets. 2019 Jun;23(6):473-483. doi: 10.1080/14728222.2019.1615883. Epub 2019 May 10.
Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers. Progress has been made in treatment of HCC; however, improved outcomes are much needed. The increased metabolic needs of cancer cells underscore the importance of metabolic pathways in cancer cell survival. Lipid metabolism has a role in HCC development; aberrant overexpression of several key enzymes is seen in many solid human tumors. Areas covered: We discuss aberrant lipid metabolism and the promise of multiple targets, in particular related to HCC treatment. We searched PubMed and clinicaltrials.gov for published and unpublished studies from 2000 to 2019. These terms were used: lipids, fatty acid metabolism, lipid metabolism, liver cancer, HCC, de novo fatty acid synthesis, ATP citrate lyase, stearoyl CoA denaturase, fatty acid synthase, acetyl coenzyme A carboxylase, CD147, KLF4, monoglyceride lipase, AMP activated protein kinase. Expert opinion: The importance of dysregulation of fatty acid synthesis in cancer is a growing area of research. HCC demonstrates significant alteration in lipid metabolism, representing great potential as a target for novel therapeutics. Various agents have demonstrated promising anti-neoplastic activity. This strategy deserves further development for improved outcomes.
肝细胞癌（HCC）是最常见和最致命的癌症之一。在 HCC 的治疗方面已经取得了进展；然而，仍非常需要改善治疗效果。癌细胞代谢需求的增加突出了代谢途径在癌细胞存活中的重要性。脂代谢在 HCC 的发展中起作用；许多实体人类肿瘤中都存在几种关键酶的异常过表达。涵盖领域：我们讨论了异常脂代谢和多个靶点的前景，特别是与 HCC 治疗相关的靶点。我们在 PubMed 和 clinicaltrials.gov 上搜索了 2000 年至 2019 年发表和未发表的研究。使用了以下术语：脂质、脂肪酸代谢、脂代谢、肝癌、HCC、从头脂肪酸合成、三磷酸腺苷柠檬酸裂解酶、硬脂酰辅酶 A 去饱和酶、脂肪酸合酶、乙酰辅酶 A 羧化酶、CD147、KLF4、单甘油酯脂肪酶、AMP 激活蛋白激酶。专家意见：脂肪酸合成失调在癌症中的重要性是一个不断发展的研究领域。HCC 显示出脂质代谢的显著改变，这为新型治疗药物提供了巨大的潜在靶点。各种药物已显示出有希望的抗肿瘤活性。这种策略值得进一步开发，以提高治疗效果。
