天然存在的Rh抗体对血清学不相容红细胞存活的影响。
The effect of naturally occurring Rh antibodies on the survival of serologically incompatible red cells.
作者信息
Contreras M, de Silva M, Teesdale P, Mollison P L
出版信息
Br J Haematol. 1987 Apr;65(4):475-8. doi: 10.1111/j.1365-2141.1987.tb04153.x.
Investigations on six males with naturally occurring Rh antibodies are described. In two subjects in whom the antibody (one anti-E and one anti-D) could be detected only by a two-stage papain technique, the survival of incompatible red cells was normal. In the remaining four subjects, the antibodies (two anti-E and two anti-D) could be detected by the indirect antiglobulin test and, in these, incompatible red cells were destroyed at an accelerated rate; in two of the subjects, 75-99% of the cells were cleared within 24 h; in the other two, 50% of the cells were cleared within 24 h and the remaining cells were cleared far more slowly. All six antibodies were mainly or wholly IgG; a clear-cut immune response was observed in only one case.
本文描述了对6名自然产生Rh抗体的男性的研究。在两名仅通过两阶段木瓜蛋白酶技术才能检测到抗体（一名抗-E和一名抗-D）的受试者中，不相容红细胞的存活正常。在其余4名受试者中，抗体（两名抗-E和两名抗-D）可通过间接抗球蛋白试验检测到，在这些受试者中，不相容红细胞以加速的速度被破坏；在两名受试者中，75-99%的细胞在24小时内被清除；在另外两名受试者中，50%的细胞在24小时内被清除，其余细胞的清除速度要慢得多。所有6种抗体主要或完全为IgG；仅在1例中观察到明确的免疫反应。
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