Ciobanasu Corina, Le Clainche Christophe
Department of Exact and Natural Sciences, Institute of Interdisciplinary Research, Alexandru I. Cuza University, Boulevard Carol I, Nr. 11, Iasi, 700506, Romania.
Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS, Gif-Sur-Yvette, 91198, France.
Cancer Metastasis Rev. 2025 Sep 9;44(3):68. doi: 10.1007/s10555-025-10287-x.
Integrins constitute a large and diverse family of cell adhesion molecules that play essential roles in regulating tumor cell differentiation, migration, proliferation, and neovascularization. Tumor cell-derived exosomes, a subtype of extracellular vesicles, are enriched with integrins that reflect their cells of origin. These exosomal integrins can promote extracellular matrix remodeling, immune suppression, and vascular remodeling and are closely linked to tumor progression and metastasis, acting as pivotal players in mediating organ-specific metastasis. The present review aims to discuss recent insights into the role of integrins from extracellular vesicles in tumor cell initiation, proliferation, migration, and invasion. Beyond their functional roles in cancer progression, exosomal integrins hold relevant potential as diagnostic and prognostic biomarkers due to their tissue-specific expression patterns. They also represent promising therapeutic targets for disrupting tumor-stroma interactions and preventing metastatic spread. As research into exosomal integrins continues to expand, they are likely to provide valuable insights into cancer biology and innovative strategies in cancer diagnosis and treatment.
整合素构成了一个庞大且多样的细胞黏附分子家族，在调节肿瘤细胞分化、迁移、增殖和新血管形成中发挥着重要作用。肿瘤细胞衍生的外泌体是细胞外囊泡的一种亚型，富含反映其起源细胞的整合素。这些外泌体整合素可促进细胞外基质重塑、免疫抑制和血管重塑，并与肿瘤进展和转移密切相关，在介导器官特异性转移中起关键作用。本综述旨在探讨细胞外囊泡中的整合素在肿瘤细胞起始、增殖、迁移和侵袭中的作用的最新见解。除了在癌症进展中的功能作用外，外泌体整合素因其组织特异性表达模式而具有作为诊断和预后生物标志物的相关潜力。它们还代表了破坏肿瘤-基质相互作用和预防转移扩散的有前景的治疗靶点。随着对外泌体整合素的研究不断扩展，它们可能会为癌症生物学以及癌症诊断和治疗的创新策略提供有价值的见解。
