Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Chin J Nat Med. 2019 Apr;17(4):291-297. doi: 10.1016/S1875-5364(19)30032-9.
Eight new annonaceous acetogenins, squamotin A-D (1-4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9-12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1-9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity.
从番荔枝种子中分离得到 8 个新的番荔枝烷型二萜类化合物，分别为 squamotin A-D（1-4）、annosquatin IV-V（5 和 6）、muricin O（7）和 squamosten B（8），以及 4 个已知化合物（9-12）。通过化学方法和光谱数据阐明了它们的结构。测试了化合物 1-9 对 3 株多药耐药细胞系的抑制活性。所有测试的化合物均表现出较强的细胞毒性。
