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《以阿尔茨海默病家庭照顾者为对象的益处发现团体干预的长期效果:群组随机、双盲对照试验》

Long-Term Outcomes of the Benefit-Finding Group Intervention for Alzheimer Family Caregivers: A Cluster-Randomized Double-Blind Controlled Trial.

机构信息

Department of Health and Physical Education (S-TC), The Education University of Hong Kong, Hong Kong; Department of Clinical Psychology (S-TC), Norwich Medical School, University of East Anglia, Norwich, United Kingdom.

Department of Psychiatry (WCC), University of Hong Kong, Hong Kong.

出版信息

Am J Geriatr Psychiatry. 2019 Sep;27(9):984-994. doi: 10.1016/j.jagp.2019.03.013. Epub 2019 Mar 26.

Abstract

OBJECTIVES

To examine the effects of the group benefit-finding therapeutic intervention (BFT) for Alzheimer family caregivers up to 10-month follow-up.

METHODS

This was a cluster-randomized double-blind controlled trial in social centers and clinics. Participants included 129 caregivers. Inclusion criteria were 1) primary caregiver aged 18 years and older and without cognitive impairment, 2) providing 14 or more care hours per week to a relative with mild-to-moderate Alzheimer disease, and 3) scoring 3 or more on the Hamilton Depression Rating Scale. Exclusion criterion was care-recipient having parkinsonism or other forms of dementia. BFT (using cognitive reappraisal to find positive meanings) was evaluated against two forms of psychoeducation as controls-standard and simplified (lectures only) psychoeducation. All interventions had eight weekly sessions of 2 hours each. Primary outcome was depressive symptoms, whereas secondary outcomes were global burden, role overload, and psychological well-being. Measures were collected at baseline, postintervention, and 4- and 10-month follow-up.

RESULTS

Mixed-effects regression showed that BFT's effect on depressive symptoms conformed to a curvilinear pattern, in which the strong initial effect leveled out after postintervention and was maintained up to 10-month follow-up; this was true when compared against either control group. The effect on global burden was less impressive but moderate effect sizes were found at the two follow-ups. For psychological well-being, there was an increase in the BFT group at 4-month follow-up and a return to baseline afterward. No effect on role overload was found.

CONCLUSION

Benefit-finding reduces depressive symptoms as well as global burden in the long-term and increases psychological well-being in the medium-term.

摘要

目的

考察团体获益探寻治疗干预(BFT)对阿尔茨海默病家庭照顾者的影响,随访时间长达 10 个月。

方法

这是一项在社会中心和诊所进行的聚类随机双盲对照试验。纳入了 129 名照顾者。纳入标准为:1)年龄 18 岁及以上且无认知障碍的主要照顾者,2)每周为轻度至中度阿尔茨海默病亲属提供 14 小时或以上的护理,3)汉密尔顿抑郁评定量表得分 3 分或以上。排除标准为照顾对象患有帕金森病或其他形式的痴呆。BFT(使用认知重评寻找积极意义)与两种形式的心理教育作为对照进行评估,标准心理教育和简化心理教育(仅讲座)。所有干预措施均有 8 周,每周 2 小时。主要结局是抑郁症状,次要结局是总体负担、角色过载和心理幸福感。在基线、干预后以及 4 个月和 10 个月随访时进行测量。

结果

混合效应回归表明,BFT 对抑郁症状的影响呈曲线模式,干预后的初始强效应趋于平稳,并在 10 个月随访时保持稳定;与任何对照组相比均如此。对总体负担的影响不那么显著,但在两个随访时间点都发现了中等效应量。对于心理幸福感,BFT 组在 4 个月随访时增加,之后恢复到基线。角色过载方面没有发现效果。

结论

获益探寻在长期内可减轻抑郁症状和总体负担,并在中期内增加心理幸福感。

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