利用植入式超声设备突破血脑屏障。
Overcoming the Blood-Brain Barrier with an Implantable Ultrasound Device.
机构信息
Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery and Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
出版信息
Clin Cancer Res. 2019 Jul 1;25(13):3750-3752. doi: 10.1158/1078-0432.CCR-19-0932. Epub 2019 May 10.
Abstract
Ultrasound-based blood-brain barrier disruption enhances drug delivery. To bypass the human skull, an implantable ultrasound emitter was developed, and proven safe and feasible in a first-in-human trial. Next development steps aim for larger field of disruption, quantification of drug levels, use of various drugs, and ultimately a pivotal trial demonstrating improved outcome..
摘要
基于超声的血脑屏障破坏增强了药物递送。为了绕过人体颅骨，开发了一种可植入的超声发射器，并在首例人体试验中证明了其安全性和可行性。下一步的发展目标是扩大破坏范围，量化药物水平，使用各种药物，最终进行一项关键性试验，证明改善治疗效果。
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