Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center and Departments of Neurological Surgery and Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Clin Cancer Res. 2019 Jul 1;25(13):3750-3752. doi: 10.1158/1078-0432.CCR-19-0932. Epub 2019 May 10.
Ultrasound-based blood-brain barrier disruption enhances drug delivery. To bypass the human skull, an implantable ultrasound emitter was developed, and proven safe and feasible in a first-in-human trial. Next development steps aim for larger field of disruption, quantification of drug levels, use of various drugs, and ultimately a pivotal trial demonstrating improved outcome..
基于超声的血脑屏障破坏增强了药物递送。为了绕过人体颅骨,开发了一种可植入的超声发射器,并在首例人体试验中证明了其安全性和可行性。下一步的发展目标是扩大破坏范围,量化药物水平,使用各种药物,最终进行一项关键性试验,证明改善治疗效果。