Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Int J Mol Sci. 2024 Sep 30;25(19):10570. doi: 10.3390/ijms251910570.
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Despite an established standard of care including surgical resection, radiation therapy, and chemotherapy, GBM unfortunately is associated with a dismal prognosis. Therefore, researchers are extensively evaluating avenues to expand GBM therapy and improve outcomes in patients with GBM. In this review, we provide a broad overview of novel GBM therapies that have recently completed or are actively undergoing study in clinical trials. These therapies expand across medical, surgical, and radiation clinical trials. We additionally review methods for improving clinical trial design in GBM.
胶质母细胞瘤（GBM）是成人中最常见的恶性原发性脑肿瘤。尽管已经确立了包括手术切除、放射治疗和化学治疗在内的标准治疗方法，但不幸的是，GBM 的预后仍然很差。因此，研究人员正在广泛评估扩大 GBM 治疗并改善 GBM 患者预后的途径。在这篇综述中，我们提供了最近在临床试验中完成或正在积极进行研究的新型 GBM 治疗方法的广泛概述。这些治疗方法涵盖了医学、外科和放射临床试验。我们还回顾了改善 GBM 临床试验设计的方法。
