生长受限胎儿的产前窒息、高乳酸血症、低血糖症和胎儿成红细胞增多症。
Prenatal asphyxia, hyperlacticaemia, hypoglycaemia, and erythroblastosis in growth retarded fetuses.
作者信息
Soothill P W, Nicolaides K H, Campbell S
出版信息
Br Med J (Clin Res Ed). 1987 Apr 25;294(6579):1051-3. doi: 10.1136/bmj.294.6579.1051.
Abstract
The umbilical venous oxygen and carbon dioxide tensions, pH, lactate and glucose concentrations, nucleated red cell (erythroblast) count, and haemoglobin concentration were measured in 38 cases of intrauterine growth retardation in which fetal blood sampling was performed by cordocentesis. The oxygen tension was below the normal mean for gestational age in 33 cases; in 14 it was below the lower limit of the 95% confidence interval for normal pregnancies. The severity of fetal hypoxia correlated significantly with fetal hypercapnia, acidosis, hyperlacticaemia, hypoglycaemia, and erythroblastosis. These findings indicate that "birth asphyxia" is not necessarily due to the process of birth.
摘要
对38例宫内生长迟缓病例进行了脐静脉氧分压、二氧化碳分压、pH值、乳酸和葡萄糖浓度、有核红细胞（成红细胞）计数及血红蛋白浓度的测定，这些病例均通过脐静脉穿刺术采集胎儿血样。33例病例的氧分压低于胎龄正常均值；14例低于正常妊娠95%置信区间的下限。胎儿缺氧的严重程度与胎儿高碳酸血症、酸中毒、高乳酸血症、低血糖症和成红细胞增多症显著相关。这些发现表明，“出生窒息”不一定是由出生过程导致的。
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本文引用的文献
1
Perinatal morbidity and mortality in small-for-dates babies: the relative importance of some maternal factors.小于胎龄儿的围产期发病率和死亡率：某些母体因素的相对重要性。
Early Hum Dev. 1981 Sep;5(4):367-75. doi: 10.1016/0378-3782(81)90017-7.
2
Problems of the small-for-dates baby.小于胎龄儿的问题。
Clin Obstet Gynaecol. 1984 Aug;11(2):499-524.
3
Polycythemia in small for gestational age infants.小于胎龄儿的红细胞增多症
J Pediatr. 1969 Nov;75(5):812-9. doi: 10.1016/s0022-3476(69)80304-5.
4
Neonatal hypoglycaemia.新生儿低血糖症
Br Med Bull. 1966 Jan;22(1):34-9. doi: 10.1093/oxfordjournals.bmb.a070433.
5
Increased gluconeogenic substrates in the small-for-gestational-age infant.小于胎龄儿体内糖异生底物增加。
N Engl J Med. 1974 Aug 15;291(7):322-8. doi: 10.1056/NEJM197408152910702.
6
Relationship of fetal hemoglobin and oxygen content to lactate concentration in Rh isoimmunized pregnancies.Rh血型同种免疫妊娠中胎儿血红蛋白、氧含量与乳酸浓度的关系。
Obstet Gynecol. 1987 Feb;69(2):268-71.
7
Ultrasound-guided sampling of umbilical cord and placental blood to assess fetal wellbeing.超声引导下采集脐带血和胎盘血以评估胎儿健康状况。
Lancet. 1986 May 10;1(8489):1065-7. doi: 10.1016/s0140-6736(86)91333-4.
8
Rapid karyotyping in non-lethal fetal malformations.
Lancet. 1986 Feb 8;1(8476):283-7. doi: 10.1016/s0140-6736(86)90824-x.
9
Hyperfibrinogenemia and polycythemia with intrauterine growth retardation in fetal lambs.胎羊高纤维蛋白原血症、红细胞增多症与宫内生长迟缓
Am J Obstet Gynecol. 1976 Feb 1;124(3):268-71. doi: 10.1016/0002-9378(76)90155-1.
10
Ultrasonic measurement of fetal abdomen circumference in the estimation of fetal weight.超声测量胎儿腹围以估计胎儿体重。
Br J Obstet Gynaecol. 1975 Sep;82(9):689-97. doi: 10.1111/j.1471-0528.1975.tb00708.x.
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