Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Environ Sci Pollut Res Int. 2019 Jun;26(18):18886-18892. doi: 10.1007/s11356-019-04656-7. Epub 2019 May 10.
Cadmium (Cd), as a toxic metal, can accumulate in kidneys and induce renal failure. This study was undertaken to evaluate the protective effects of Allium hirtifolium Boiss bulbs against Cd-induced renal failure in rats. Thirty-six rats were divided into 6 groups: group 1, 2, and 3 received vehicle, Cd (100 mg/L/day by drinking water), and AhB extract (200 mg/kg/day; orally), respectively. Groups 4, 5, and 6 were Cd groups which treated AhB extract (50, 100, and 200 mg/kg/day, respectively). After 2 weeks, renal function and oxidative stress markers were determined by using colorimetric methods. Our findings showed that Cd caused a significant increase in creatinine (Cr; p<0.05), uric acid (p<0.01), BUN (p<0.05), serum levels, lipid peroxidation (LPO; p<0.01), and nitric oxide (NO; p<0.01); the depletion of the total antioxidant capacity (TAC; p<0.01) and total thiol molecules (TTM; p<0.001); and structural alterations in the renal tissue. Following AhB extract administration, a remarkable improvement was observed in the functional and oxidative stress markers of renal tissue.This study suggests that AhB may prevent progression of Cd-induced renal failure via improvement of oxidative/antioxidant balance in renal tissue.
镉（Cd）作为一种有毒金属，可在肾脏中积累并导致肾衰竭。本研究旨在评估韭菜鳞茎提取物对大鼠镉诱导的肾衰竭的保护作用。将 36 只大鼠分为 6 组：第 1、2 和 3 组分别给予载体、Cd（每天 100mg/L 通过饮用水）和 AhB 提取物（每天 200mg/kg；口服）。第 4、5 和 6 组为 Cd 组，分别给予 AhB 提取物（50、100 和 200mg/kg/天）。2 周后，采用比色法测定肾功能和氧化应激标志物。我们的研究结果表明，Cd 导致肌酐（Cr；p<0.05）、尿酸（p<0.01）、BUN（p<0.05）、血清水平、脂质过氧化（LPO；p<0.01）和一氧化氮（NO；p<0.01）显著升高；总抗氧化能力（TAC；p<0.01）和总巯基分子（TTM；p<0.001）耗竭；以及肾组织结构改变。给予 AhB 提取物后，肾组织的功能和氧化应激标志物显著改善。本研究表明，AhB 可能通过改善肾组织的氧化/抗氧化平衡来预防 Cd 诱导的肾衰竭的进展。
