NUTRIM School for Nutrition and Translational Research in Metabolism, University of Maastricht, Maastricht, the Netherlands.
CAPHRI School for Public Health and Primary Care, University of Maastricht, Maastricht, the Netherlands.
BJU Int. 2019 Dec;124(6):984-991. doi: 10.1111/bju.14804. Epub 2019 Jun 7.
To quantify the health-related quality of life (HRQoL) of patients with bladder cancer around the time of diagnosis and to test the hypotheses of a two-factor model for the HRQoL questionnaire QLQ-C30.
From participants in the Bladder Cancer Prognoses Programme, a multicentre cohort study, sociodemographic data were collected using semi-structured face-to-face interviews. Answers to the QLQ-C30 were transformed into a scale from 0 to 100. HRQoL data were analysed in multivariate analyses. The hypothesized two-factor (Physical and Mental Health) domain structure of the QLQ-C30 was also tested with confirmatory factor analyses (CFA).
A total of 1160 participants (78%) completed the questionnaire after initial visual diagnosis and before pathological confirmation. Despite non-muscle-invasive bladder cancer (NMIBC) being associated with a higher HRQoL than carcinoma invading bladder muscle, only the domain Role Functioning was clinically significantly better in patients with NMIBC. Age, gender, bladder cancer stage and comorbidity all had a significant influence on QLQ-C30 scores. The CFA showed an overall good fit of the hypothesized two-factor model.
This study identified a baseline reference value for HRQoL for patients with bladder cancer, which allows better evaluation of any changes in HRQoL as disease progresses or after treatment. In addition, a two-factor (Physical and Mental Health) model was developed for the QLQ-C30.
在膀胱癌诊断时量化患者的健康相关生活质量（HRQoL），并检验 HRQoL 问卷 QLQ-C30 的两因素模型假设。
从多中心队列研究膀胱癌预后计划的参与者中，通过半结构化面对面访谈收集社会人口统计学数据。QLQ-C30 的答案转换为 0 到 100 的量表。使用多变量分析对 HRQoL 数据进行分析。还使用验证性因子分析（CFA）检验了 QLQ-C30 的假设两因素（身体和心理健康）结构。
共有 1160 名参与者（78%）在初始视觉诊断后和病理确认前完成了问卷。尽管非肌肉浸润性膀胱癌（NMIBC）与更高的 HRQoL 相关，而膀胱癌侵犯肌肉的患者，仅角色功能领域在临床上表现更好。年龄、性别、膀胱癌分期和合并症都对 QLQ-C30 评分有显著影响。CFA 显示假设的两因素模型总体拟合良好。
本研究确定了膀胱癌患者 HRQoL 的基线参考值，这可以更好地评估疾病进展或治疗后 HRQoL 的任何变化。此外，还为 QLQ-C30 开发了两因素（身体和心理健康）模型。
