Vasků J
Czech Med. 1987;10(1):16-28.
The implications of mineralization on the diaphragm of a TAH were highlighted. The problem was discussed from the point of view of time and site of calcifying deposit formation, and individual patterns of calcification as well as the question of the relationship between mineralization processes and thrombogenicity were considered. Attention was likewise given to actual calcification with regard to its mechanism, and to the risks that the calcification process in an artificial heart pose to the organism. Next, the options to prevent mineralization were reviewed. The issue as analysed especially on the basis of results obtained in the Centre of the State Research project called "Assistance and Replacement of the Heart", Regional Institute of National Health in Brno, Department of Pathological Physiology. It was pointed out that diaphragm calcification can compromise the life of an individual after many years of surviving with an artificial heart. Still, the risk is zero within the first two or three months following artificial heart implantation. The fact was underlined that the last model of a Czechoslovak-made artificial heart, called TNS Brno VII, re-designed in an effort to prevent the breaking away of calcified microemboli from the diaphragm, features optimal athrombogenity. Thus, the clinical version of this brand-new Czechoslovak TAH can be regarded as the best model of an artificial heart to be implanted as a life-saving measure tiding the patient over a period before a cardiac transplantation can be performed.
强调了TAH隔膜矿化的影响。从钙化沉积物形成的时间和部位、个体钙化模式以及矿化过程与血栓形成性之间关系的问题等角度对该问题进行了讨论。同样关注了实际钙化的机制以及人工心脏中的钙化过程对机体造成的风险。接下来，回顾了预防矿化的方法。该问题尤其根据在布尔诺国家卫生区域研究所病理生理学系名为“心脏辅助与替代”的国家研究项目中心获得的结果进行了分析。指出隔膜钙化可能在患者依靠人工心脏存活多年后危及生命。不过，在人工心脏植入后的头两三个月内风险为零。着重强调了捷克斯洛伐克制造的最后一款人工心脏模型TNS布尔诺VII，为防止钙化微栓子从隔膜脱落而重新设计，具有最佳的抗血栓形成性。因此，这款全新的捷克斯洛伐克TAH临床版本可被视为作为挽救生命措施植入的最佳人工心脏模型，使患者在能够进行心脏移植之前的一段时间内度过难关。
