Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Sergio Pansini 5, Naples 80131, Italy.
Heart Fail Clin. 2019 Jul;15(3):393-398. doi: 10.1016/j.hfc.2019.02.008. Epub 2019 Apr 5.
The cardiovascular system is one of the main targets of thyroid hormone action, and triiodothyronine deficiency has crucial consequences on cardiac structure and function. Patients with overt or subclinical hypothyroidism should be treated with levothyroxine to improve their cardiovascular function and the potential risk of heart failure. Even patients with thyroid hormone deficiency and heart failure should receive replacement doses of levothyroxine to improve their prognosis and worsening of the cardiovascular function. An innovative therapeutic multifactorial approach could improve the progression of heart failure. There is a potential beneficial effect of thyroid hormones and their analogs in patients with heart failure.
心血管系统是甲状腺激素作用的主要靶器官之一，三碘甲状腺原氨酸缺乏对心脏结构和功能有重要影响。对于显性或亚临床甲状腺功能减退症的患者，应使用左甲状腺素进行治疗，以改善其心血管功能和心力衰竭的潜在风险。甚至对于甲状腺激素缺乏和心力衰竭的患者，也应给予左甲状腺素替代剂量，以改善其预后和心血管功能恶化。创新的治疗多因素方法可能会改善心力衰竭的进展。甲状腺激素及其类似物对心力衰竭患者可能具有潜在的有益作用。
