35519 例患者中现症感染和代谢因素与胃癌的相关性：一项横断面研究。
Association of current infection and metabolic factors with gastric cancer in 35,519 subjects: A cross-sectional study.
机构信息
Gastroenterology, Center for Gastric Cancer, Kyungpook National University Hospital, Daegu, Korea.
Department of Internal Medicine, Center for Cancer Prevention and Detection, Goyang, Korea.
出版信息
United European Gastroenterol J. 2019 Mar;7(2):287-296. doi: 10.1177/2050640618819402. Epub 2018 Dec 12.
BACKGROUND
The effect of current infection of on gastric cancer has rarely been studied in a large population. We investigated the association of current infection and metabolic factors with gastric cancer in a large population.
METHODS
Persons who made their first visit to the National Cancer Center for a health examination, including endoscopy and testing using gastric tissue between 2003 and 2013, were included. The association of with gastric cancer was estimated using odds ratios (ORs) and 95% confidence intervals (CIs).
RESULTS
Among 35,519 people, 113 gastric cancer and 158 gastric dysplasia cases were detected. In the adjusted analysis, gastric cancer was associated with current infection (OR, 2.39; 95% CI, 1.53-3.74), age (OR, 1.06; 95% CI 1.04-1.08), first-degree relatives with gastric cancer (OR, 2.08; 95% CI, 1.30-3.32) and hyperglycaemia (OR, 1.66; 95% CI, 1.04-2.65), whereas it was inversely associated with high-density lipoprotein (HDL) (OR, 0.49; 95% CI, 0.22-0.94). In the subanalysis, gastric cancer was associated with first-degree relatives with gastric cancer (OR, 3.23; 95% CI, 1.39-7.50) in the absence of , whereas it was associated with hyperglycaemia (OR, 1.98; 95% CI, 1.16-3.39) in the presence of
CONCLUSIONS
Gastric cancer was associated with current infection, hyperglycaemia, and low HDL levels in a large population.
背景
目前 感染对胃癌的影响在很大一部分人群中很少被研究。我们在一个大人群中调查了当前 感染和代谢因素与胃癌的关系。
方法
纳入 2003 年至 2013 年间首次到国家癌症中心进行体检的人群，包括内镜检查和胃组织的 检测。使用比值比（ORs）和 95%置信区间（CIs）来估计 与胃癌的关系。
结果
在 35519 人中，发现了 113 例胃癌和 158 例胃黏膜异型增生病例。在调整分析中，胃癌与当前 感染（OR，2.39；95%CI，1.53-3.74）、年龄（OR，1.06；95%CI，1.04-1.08）、一级亲属有胃癌（OR，2.08；95%CI，1.30-3.32）和高血糖（OR，1.66；95%CI，1.04-2.65）有关，而与高密度脂蛋白（HDL）呈负相关（OR，0.49；95%CI，0.22-0.94）。在亚组分析中，在没有 的情况下，胃癌与一级亲属有胃癌（OR，3.23；95%CI，1.39-7.50）有关，而在有 的情况下，胃癌与高血糖（OR，1.98；95%CI，1.16-3.39）有关。
结论
在一个大人群中，胃癌与当前的 感染、高血糖和低 HDL 水平有关。
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