Seoul National University Hospital, Healthcare System Gangnam Center, Healthcare Research Institute, Seoul, Korea.
Gut Liver. 2007 Jun;1(1):33-9. doi: 10.5009/gnl.2007.1.1.33. Epub 2007 Jun 30.
BACKGROUND/AIMS: Gastric cancer is the leading malignancy in Korea and early detection through the health screening seems to be important. The aims of this study were to investigate the features of gastric neoplasms detected during screening, and to figure out the risk factors of these lesions.
From October 2003 to September 2005, subjects who visited Seoul National University Hospital Healthcare System Gangnam Center for health check-up were included in the study. The program included a questionnaire and tests including anti-Helicobacter pylori (H. pylori) antibody, esophagogastroduodenoscopy or double contrast upper gastrointestinal study. To figure out the risk factors, an age and gender-matched, four-fold sized control group was selected from the subjects.
Of 25, 432 subjects, 122 cases of gastric neoplasms were detected including 61 adenocarcinoma (45 early gastric cancers), 53 adenoma, 7 mucosa-associated lymphoid tissue lymphoma, and one metastatic cancer. There was no significant statistical difference in basal characteristics of the subjects between gastric adenocarcinoma and adenoma. When comparing with the control group those without gastric neoplasms, smoking history, family history of stomach cancer, and H. pylori seropositivity were found to be significant risk factors for gastric neoplasms. Metabolic syndrome was more prevalent in adenoma than in the control (p<0.05).
The health screening may be beneficial in early detection of gastric cancer. In addition, metabolic syndrome might be related with gastric adenoma.
背景/目的：胃癌是韩国最主要的恶性肿瘤，通过健康筛查早期发现胃癌似乎很重要。本研究的目的是调查筛查中发现的胃肿瘤的特征，并找出这些病变的危险因素。
本研究纳入了 2003 年 10 月至 2005 年 9 月期间在首尔国立大学医院保健系统江南中心进行健康检查的对象。该项目包括问卷调查和包括抗幽门螺杆菌（H. pylori）抗体、食管胃十二指肠镜检查或双重对比上消化道研究在内的检查。为了找出危险因素，从研究对象中选择了年龄和性别匹配的四倍大小的对照组。
在 25432 名受试者中，共发现 122 例胃肿瘤，包括 61 例腺癌（45 例早期胃癌）、53 例腺瘤、7 例黏膜相关淋巴组织淋巴瘤和 1 例转移性癌。胃腺癌和腺瘤患者的基本特征无统计学差异。与无胃肿瘤的对照组相比，吸烟史、胃癌家族史和 H. pylori 血清阳性被发现是胃肿瘤的显著危险因素。与对照组相比，代谢综合征在腺瘤中更为常见（p<0.05）。
健康筛查可能有助于早期发现胃癌。此外，代谢综合征可能与胃腺瘤有关。
