从 根部分离得到一对新的贝壳杉烷二萜类差向异构体及其抗炎活性。
A pair of new -clerodane diterpenoid epimers from the roots of and their anti-inflammatory.
机构信息
Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi University of Chinese Medicine, Xianyang, P.R. China.
Bao Ji University of Arts and Sciences, Baoji, P.R. China.
出版信息
Nat Prod Res. 2020 Oct;34(20):2945-2951. doi: 10.1080/14786419.2019.1601193. Epub 2019 May 13.
A pair of new clerodane diterpenoid epimers, 3-methoxyl-teucvin () and 3-methoxyl-teucvin (), were isolated from the Roots of Their structures were completely established on the basis of spectroscopic methods, and the absolute configurations were determined by analysis of electronic circular dichroism (ECD) spectroscopy and X-ray diffraction analysis. Compounds and exhibited anti-inflammatory activities with IC values of 0.82 and 0.54 μM, respectively, while the IC value of dexamethasone as a positive control was found to be 0.14 μM.
一对新的 clerodane 二萜类差向异构体，3-甲氧基-teucvin（）和 3-甲氧基-teucvin（），从根中分离出来。它们的结构完全是根据光谱方法确定的，绝对构型是通过分析电子圆二色性（ECD）光谱和 X 射线衍射分析确定的。化合物和表现出抗炎活性，IC 值分别为 0.82 和 0.54 μM，而作为阳性对照的地塞米松的 IC 值为 0.14 μM。
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