Gaafar Ahmed G, Abo-Youssef Amira M, Khalaf Marwa M, Abo-Saif Ali A
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Pak J Pharm Sci. 2019 Mar;32(2):593-600.
The current study was designed to explore the protecting effects of vitamin D and losartan in treatment of rheumatoid arthritis (RA). Animals were allotted to five groups: Group I received vehicles only (vehicle control). Group II was administered complete Freund's adjuvant (CFA) and did not receive any medication. The remaining three groups (III, IV, V) were given CFA followed by treatment with leflunomide, vitamin D or losartan, respectively for two weeks. Compelling increment in tumor necrosis factor (TNF-α), interleukin 6 (IL-6), rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), malondialdehyde (MDA) level, white blood cells (WBCs), total cholesterol (TC) and triglycerides (TGs) was revealed in arthritic rats. This was associated with marked decline in glutathione (GSH) level, red blood cells (RBCs), hemoglobin (Hb), Platelets (Plts), hematocrit (Hct) and high density lipoprotein cholesterol (HDL). vitamin D or losartan significantly decreased TNF α, IL-6, RF, ESR, MDA, TC, TGs, WBCs and significantly increased RBCs, Hb, Hct, Plts and HDL. It could be concluded that vitamin D and losartan are able to repress the alterations associated with adjuvant-induced arthritis (AIA). This preserving effect might be partially attributed to antiarithritic, hypolipidemic and antianemic properties.
本研究旨在探讨维生素D和氯沙坦在类风湿性关节炎（RA）治疗中的保护作用。将动物分为五组：第一组仅给予赋形剂（赋形剂对照组）。第二组给予完全弗氏佐剂（CFA），不接受任何药物治疗。其余三组（第三组、第四组、第五组）给予CFA，随后分别用来氟米特、维生素D或氯沙坦治疗两周。关节炎大鼠的肿瘤坏死因子（TNF-α）、白细胞介素6（IL-6）、类风湿因子（RF）、红细胞沉降率（ESR）、丙二醛（MDA）水平、白细胞（WBC）、总胆固醇（TC）和甘油三酯（TG）显著升高。这与谷胱甘肽（GSH）水平、红细胞（RBC）、血红蛋白（Hb）、血小板（Plts）、血细胞比容（Hct）和高密度脂蛋白胆固醇（HDL）的显著下降有关。维生素D或氯沙坦可显著降低TNF-α、IL-6、RF、ESR、MDA、TC、TG、WBC，并显著升高RBC、Hb、Hct、Plts和HDL。可以得出结论，维生素D和氯沙坦能够抑制与佐剂性关节炎（AIA）相关的改变。这种保护作用可能部分归因于抗关节炎、降血脂和抗贫血特性。
