Ali Eman A I, Barakat Bassant M, Hassan Ranya
Department of Histology & Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Department of Pharmacology & Toxicology, Faculty of Pharmacy (Girls), Al Azhar University, Cairo, Egypt.
PLoS One. 2015 Apr 8;10(4):e0121523. doi: 10.1371/journal.pone.0121523. eCollection 2015.
Currently, natural products have built a well-recognized role in the management of many degenerative diseases, mainly rheumatoid arthritis. Recent studies suggest that Spirulina, a unicellular blue-green alga, may have a variety of health benefits and curative properties and is also competent of acting as an anti-inflammatory, antioxidant and recently anti-angiogenic agent. In the present study, the antioxidant and the immunomodulatory effect of Spirulina platensis as well as its anti-angiogenic effect against complete Freund's adjuvant-induced arthritis (AIA) in rat model were tested.
We found that the development of arthritis was concealed; moreover it successfully inhibited the development of macroscopic as well as microscopic and histopathological lesions in AIA rats when compared to control. Spirulina treated group showed a higher survival rate and moreover, it reduced the clinical score of RA in a dose dependent manner. Furthermore, Spirulina decreased serum levels of COX-2, TNF-α, IL-6, TBARS, VEGF and increased serum levels of GSH compared to the RA non-treated group.
The present study concluded that Spirulina is able to restrain the changes produced through adjuvant-induced arthritis. The suppressing effect of Spirulina could be attributed, at least in part, to anti-inflammatory, antioxidant and anti-angiogenic properties.
目前，天然产物在许多退行性疾病（主要是类风湿性关节炎）的治疗中已发挥了公认的作用。最近的研究表明，螺旋藻，一种单细胞蓝绿藻，可能具有多种健康益处和治疗特性，并且还能够作为抗炎、抗氧化剂以及最近发现的抗血管生成剂。在本研究中，测试了钝顶螺旋藻的抗氧化和免疫调节作用以及其对大鼠完全弗氏佐剂诱导性关节炎（AIA）的抗血管生成作用。
我们发现关节炎的发展被抑制；此外，与对照组相比，它成功抑制了AIA大鼠宏观以及微观和组织病理学损伤的发展。螺旋藻治疗组显示出更高的存活率，而且，它以剂量依赖的方式降低了类风湿性关节炎的临床评分。此外，与未治疗的类风湿性关节炎组相比，螺旋藻降低了血清中COX-2、TNF-α、IL-6、TBARS、VEGF的水平，并提高了血清中GSH的水平。
本研究得出结论，螺旋藻能够抑制佐剂诱导性关节炎产生的变化。螺旋藻的抑制作用至少部分可归因于其抗炎、抗氧化和抗血管生成特性。
