Hancock M R, Knapp M L, Ghany H C, Mayne P D
J Clin Pathol. 1987 Apr;40(4):409-11. doi: 10.1136/jcp.40.4.409.
The effects of heat treatment of serum samples on the hormone analyses used in this laboratory were studied. Total T4, testosterone, progesterone, and growth hormone were not systematically affected by heat treatment over the whole range of analyte concentrations studied; for thyroid stimulating hormone, no effect was noted on serum samples with concentrations of less than 10 mU/l. Significant changes occurred in total T3, cortisol, follicle stimulating hormone, luteinizing hormone, and prolactin. It is suggested that with appropriate preliminary study, heat treated plasma samples may be used in endocrinological investigations without adversely affecting the diagnostic validity of the results.
研究了血清样本热处理对本实验室所用激素分析的影响。在所研究的分析物浓度范围内，总T4、睾酮、孕酮和生长激素未受到热处理的系统性影响；对于促甲状腺激素，浓度低于10 mU/l的血清样本未观察到影响。总T3、皮质醇、促卵泡激素、促黄体生成素和催乳素发生了显著变化。建议经过适当的初步研究后，热处理的血浆样本可用于内分泌学研究，而不会对结果的诊断有效性产生不利影响。
