β2微球蛋白（β2m）的细胞表面表达与B细胞肿瘤的分化阶段相关。
Cell surface expression of beta 2-microglobulin (beta 2m) correlates with stages of differentiation in B cell tumours.
作者信息
Jones R A, Scott C S, Norfolk D R, Stark A N, Child J A
出版信息
J Clin Pathol. 1987 May;40(5):486-9. doi: 10.1136/jcp.40.5.486.
Cell surface beta 2-microglobulin (beta 2m) densities of malignant B cells were determined by enzyme immunoassay in 97 cases of immunologically defined lymphoproliferative disease. Absolute beta 2m densities were found to depend on disease category with the lowest levels found on cells from chronic lymphocytic leukaemia (mean = 5.6 ng/10(6) cells, n = 27); atypical chronic lymphocytic leukaemia (mean = 5.9 ng/10(6) cells, n = 8); and prolymphocytoid chronic lymphocytic leukaemia variant (mean = 6.0 ng/10(6) cells, n = 16). beta 2m densities for B non-Hodgkin's lymphoma (n = 14) and B prolymphocytic leukaemia (n = 17) cases were 8.1 and 10.0 ng/10(6) cells, respectively, and the highest densities were found on cells from "late-B cell" tumours (mean = 14.3 ng/10(6) cells). Plasma cells from cases of Ig secreting tumours expressed unexpectedly low beta 2m densities (mean = 9.3 ng/10(6) cells; n = 6).
采用酶免疫测定法测定了97例免疫学分型的淋巴增殖性疾病患者恶性B细胞的细胞表面β2微球蛋白（β2m）密度。发现绝对β2m密度取决于疾病类型，慢性淋巴细胞白血病细胞（平均值=5.6 ng/10⁶细胞，n=27）、非典型慢性淋巴细胞白血病（平均值=5.9 ng/10⁶细胞，n=8）和原淋巴细胞样慢性淋巴细胞白血病变异型（平均值=6.0 ng/10⁶细胞，n=16）的细胞β2m密度最低。B非霍奇金淋巴瘤（n=14）和B原淋巴细胞白血病（n=17）患者的β2m密度分别为8.1和10.0 ng/10⁶细胞，“晚期B细胞”肿瘤细胞的β2m密度最高（平均值=14.3 ng/10⁶细胞）。分泌Ig的肿瘤患者的浆细胞表达的β2m密度出乎意料地低（平均值=9.3 ng/10⁶细胞；n=6）。
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